# MRIQT: Physics-Aware Diffusion Model for Image Quality Transfer in Neonatal Ultra-Low-Field MRI

arXiv: https://arxiv.org/abs/2511.13232 · HTML: https://mlsanity.com/paper/2511.13232/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 11 of its 25 references that are in the map.
- First posted on arXiv 17 Nov 2025.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 11 of 11)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Efficiently Modeling Long Sequences with Structured State Spaces](https://mlsanity.com/paper/2111.00396/) (2021)
- [Image Super-Resolution via Iterative Refinement](https://mlsanity.com/paper/2104.07636/) (2021)
- [Conditional Diffusion Models for Semantic 3D Brain MRI Synthesis](https://mlsanity.com/paper/2305.18453/) (2023)
- [Patch-Based Image Inpainting with Generative Adversarial Networks](https://mlsanity.com/paper/1803.07422/) (2018)
- [Joint super-resolution and synthesis of 1 mm isotropic MP-RAGE volumes from clinical MRI exams with scans of different orientation, resolution and contrast](https://mlsanity.com/paper/2012.13340/) (2020)
- [A 3D Conditional Diffusion Model for Image Quality Transfer -- An Application to Low-Field MRI](https://mlsanity.com/paper/2311.06631/) (2023)
- [GAMBAS: Generalised-Hilbert Mamba for Super-resolution of Paediatric Ultra-Low-Field MRI](https://mlsanity.com/paper/2504.04523/) (2025)

## Built on by (most cited first, 2 of 2)

- [ULF-Synth: Physics-Guided Ultra-Low-Field MRI Enhancement for Pediatric Neuroimaging](https://mlsanity.com/paper/2605.24625/) (2026)
- [Evaluating the Safety of Deep Learning-Based Brain MRI Reconstruction](https://mlsanity.com/paper/2608.28714/) (2026)

## Abstract (arXiv)

Portable ultra-low-field MRI (uLF-MRI, 0.064 T) offers accessible neuroimaging for neonatal care but suffers from low signal-to-noise ratio and poor diagnostic quality compared to high-field (HF) MRI. We propose MRIQT, a 3D conditional diffusion framework for image quality transfer (IQT) from uLF to HF MRI. MRIQT combines realistic K-space degradation for physics-consistent uLF simulation, v-prediction with classifier-free guidance for stable image-to-image generation, and an SNR-weighted 3D perceptual loss for anatomical fidelity. The model denoises from a noised uLF input conditioned on the same scan, leveraging volumetric attention-UNet architecture for structure-preserving translation. Trained on a neonatal cohort with diverse pathologies, MRIQT surpasses recent GAN and CNN baselines in PSNR 15.3% with 1.78% over the state of the art, while physicians rated 85% of its outputs as good quality with clear pathology present. MRIQT enables high-fidelity, diffusion-based enhancement of portable ultra-low-field (uLF) MRI for deliable neonatal brain assessment.