# Uncertainty-aware Physics-informed Neural Networks for Robust CARS-to-Raman Signal Reconstruction

arXiv: https://arxiv.org/abs/2511.13185 · HTML: https://mlsanity.com/paper/2511.13185/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 29 references that are in the map.
- First posted on arXiv 17 Nov 2025.

## Builds on (most cited first, 9 of 9)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [Dropout as a Bayesian Approximation: Representing Model Uncertainty in Deep Learning](https://mlsanity.com/paper/1506.02142/) (2015)
- [Simple and Scalable Predictive Uncertainty Estimation using Deep Ensembles](https://mlsanity.com/paper/1612.01474/) (2016)
- [Accurate Uncertainties for Deep Learning Using Calibrated Regression](https://mlsanity.com/paper/1807.00263/) (2018)
- [Physics Informed Deep Learning (Part II): Data-driven Discovery of Nonlinear Partial Differential Equations](https://mlsanity.com/paper/1711.10566/) (2017)
- [Do Bayesian Neural Networks Need To Be Fully Stochastic?](https://mlsanity.com/paper/2211.06291/) (2022)
- [Gaussian Latent Representations for Uncertainty Estimation using Mahalanobis Distance in Deep Classifiers](https://mlsanity.com/paper/2305.13849/) (2023)
- [Distance-informed Neural Processes](https://mlsanity.com/paper/2508.18903/) (2025)

## Abstract (arXiv)

Coherent anti-Stokes Raman scattering (CARS) spectroscopy is a powerful and rapid technique widely used in medicine, material science, and chemical analyses. However, its effectiveness is hindered by the presence of a non-resonant background that interferes with and distorts the true Raman signal. Deep learning methods have been employed to reconstruct the true Raman spectrum from measured CARS data using labeled datasets. A more recent development integrates the domain knowledge of Kramers-Kronig relationships and smoothness constraints in the form of physics-informed loss functions. However, these deterministic models lack the ability to quantify uncertainty, an essential feature for reliable deployment in high-stakes scientific and biomedical applications. In this work, we evaluate and compare various uncertainty quantification (UQ) techniques within the context of CARS-to-Raman signal reconstruction. Furthermore, we demonstrate that incorporating physics-informed constraints into these models improves their calibration, offering a promising path toward more trustworthy CARS data analysis.