# TCM-5CEval: Extended Deep Evaluation Benchmark for LLM's Comprehensive Clinical Research Competence in Traditional Chinese Medicine

arXiv: https://arxiv.org/abs/2511.13169 · HTML: https://mlsanity.com/paper/2511.13169/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 32 references that are in the map.
- First posted on arXiv 17 Nov 2025.

## Builds on (most cited first, 9 of 9)

- [Empowering LLMs with Logical Reasoning: A Comprehensive Survey](https://mlsanity.com/paper/2502.15652/) (2025)
- [Reasoning Abilities of Large Language Models: In-Depth Analysis on the Abstraction and Reasoning Corpus](https://mlsanity.com/paper/2403.11793/) (2024)
- [Leveraging Medical Knowledge Graphs Into Large Language Models for Diagnosis Prediction: Design and Application Study](https://mlsanity.com/paper/2308.14321/) (2023)
- [Assessing the Impact of Automated Suggestions on Decision Making: Domain Experts Mediate Model Errors but Take Less Initiative](https://mlsanity.com/paper/2103.04725/) (2021)
- [TCMBench: A Comprehensive Benchmark for Evaluating Large Language Models in Traditional Chinese Medicine](https://mlsanity.com/paper/2406.01126/) (2024)
- [TCMD: A Traditional Chinese Medicine QA Dataset for Evaluating Large Language Models](https://mlsanity.com/paper/2406.04941/) (2024)
- [TCM-Ladder: A Benchmark for Multimodal Question Answering on Traditional Chinese Medicine](https://mlsanity.com/paper/2505.24063/) (2025)
- [TCM-3CEval: A Triaxial Benchmark for Assessing Responses from Large Language Models in Traditional Chinese Medicine](https://mlsanity.com/paper/2503.07041/) (2025)
- [MTCMB: A Multi-Task Benchmark Framework for Evaluating LLMs on Knowledge, Reasoning, and Safety in Traditional Chinese Medicine](https://mlsanity.com/paper/2506.01252/) (2025)

## Abstract (arXiv)

Large language models (LLMs) have demonstrated exceptional capabilities in general domains, yet their application in highly specialized and culturally-rich fields like Traditional Chinese Medicine (TCM) requires rigorous and nuanced evaluation. Building upon prior foundational work such as TCM-3CEval, which highlighted systemic knowledge gaps and the importance of cultural-contextual alignment, we introduce TCM-5CEval, a more granular and comprehensive benchmark. TCM-5CEval is designed to assess LLMs across five critical dimensions: (1) Core Knowledge (TCM-Exam), (2) Classical Literacy (TCM-LitQA), (3) Clinical Decision-making (TCM-MRCD), (4) Chinese Materia Medica (TCM-CMM), and (5) Clinical Non-pharmacological Therapy (TCM-ClinNPT). We conducted a thorough evaluation of fifteen prominent LLMs, revealing significant performance disparities and identifying top-performing models like deepseekr1 and gemini25pro. Our findings show that while models exhibit proficiency in recalling foundational knowledge, they struggle with the interpretative complexities of classical texts. Critically, permutation-based consistency testing reveals widespread fragilities in model inference. All evaluated models, including the highest-scoring ones, displayed a substantial performance degradation when faced with varied question option ordering, indicating a pervasive sensitivity to positional bias and a lack of robust understanding. TCM-5CEval not only provides a more detailed diagnostic tool for LLM capabilities in TCM but aldso exposes fundamental weaknesses in their reasoning stability. To promote further research and standardized comparison, TCM-5CEval has been uploaded to the Medbench platform, joining its predecessor in the "In-depth Challenge for Comprehensive TCM Abilities" special track.