# Genomic Next-Token Predictors are In-Context Learners

arXiv: https://arxiv.org/abs/2511.12797 · HTML: https://mlsanity.com/paper/2511.12797/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 69 of its 96 references that are in the map.
- First posted on arXiv 16 Nov 2025.

## Builds on (most cited first, 30 of 69)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [Training Verifiers to Solve Math Word Problems](https://mlsanity.com/paper/2110.14168/) (2021)
- [ReAct: Synergizing Reasoning and Acting in Language Models](https://mlsanity.com/paper/2210.03629/) (2022)
- [Scaling Laws for Neural Language Models](https://mlsanity.com/paper/2001.08361/) (2020)
- [BLIP-2: Bootstrapping Language-Image Pre-training with Frozen Image Encoders and Large Language Models](https://mlsanity.com/paper/2301.12597/) (2023)
- [Model-Agnostic Meta-Learning for Fast Adaptation of Deep Networks](https://mlsanity.com/paper/1703.03400/) (2017)
- [Flamingo: a Visual Language Model for Few-Shot Learning](https://mlsanity.com/paper/2204.14198/) (2022)
- [Large Language Models are Zero-Shot Reasoners](https://mlsanity.com/paper/2205.11916/) (2022)
- [BLIP: Bootstrapping Language-Image Pre-training for Unified Vision-Language Understanding and Generation](https://mlsanity.com/paper/2201.12086/) (2022)
- [Self-Refine: Iterative Refinement with Self-Feedback](https://mlsanity.com/paper/2303.17651/) (2023)
- [Self-Instruct: Aligning Language Models with Self-Generated Instructions](https://mlsanity.com/paper/2212.10560/) (2022)
- [In-context Learning and Induction Heads](https://mlsanity.com/paper/2209.11895/) (2022)
- [An Explanation of In-context Learning as Implicit Bayesian Inference](https://mlsanity.com/paper/2111.02080/) (2021)
- [Show Your Work: Scratchpads for Intermediate Computation with Language Models](https://mlsanity.com/paper/2112.00114/) (2021)
- [Chronos: Learning the Language of Time Series](https://mlsanity.com/paper/2403.07815/) (2024)
- [Did Aristotle Use a Laptop? A Question Answering Benchmark with Implicit Reasoning Strategies](https://mlsanity.com/paper/2101.02235/) (2021)
- [What Can Transformers Learn In-Context? A Case Study of Simple Function Classes](https://mlsanity.com/paper/2208.01066/) (2022)
- [A decoder-only foundation model for time-series forecasting](https://mlsanity.com/paper/2310.10688/) (2023)
- [What learning algorithm is in-context learning? Investigations with linear models](https://mlsanity.com/paper/2211.15661/) (2022)
- [Zephyr: Direct Distillation of LM Alignment](https://mlsanity.com/paper/2310.16944/) (2023)
- [MetaICL: Learning to Learn In Context](https://mlsanity.com/paper/2110.15943/) (2021)
- [Generative Multimodal Models are In-Context Learners](https://mlsanity.com/paper/2312.13286/) (2023)
- [Meta-learning with differentiable closed-form solvers](https://mlsanity.com/paper/1805.08136/) (2018)
- [Data Distributional Properties Drive Emergent In-Context Learning in Transformers](https://mlsanity.com/paper/2205.05055/) (2022)
- [Transformers learn to implement preconditioned gradient descent for in-context learning](https://mlsanity.com/paper/2306.00297/) (2023)
- [Emergent Analogical Reasoning in Large Language Models](https://mlsanity.com/paper/2212.09196/) (2022)
- [Label Words are Anchors: An Information Flow Perspective for Understanding In-Context Learning](https://mlsanity.com/paper/2305.14160/) (2023)
- [Transformers as Algorithms: Generalization and Stability in In-context Learning](https://mlsanity.com/paper/2301.07067/) (2023)
- [Sequential Modeling Enables Scalable Learning for Large Vision Models](https://mlsanity.com/paper/2312.00785/) (2023)

## Built on by (most cited first, 1 of 1)

- [Convergent Emergence of In-Context Learning Across Modalities](https://mlsanity.com/paper/2609.14011/) (2026)

## Abstract (arXiv)

In-context learning (ICL) -- the capacity of a model to infer and apply abstract patterns from examples provided within its input -- has been extensively studied in large language models trained for next-token prediction on human text. In fact, prior work often attributes this emergent behavior to distinctive statistical properties in human language. This raises a fundamental question: can ICL arise organically in other sequence domains purely through large-scale predictive training? To explore this, we turn to genomic sequences, an alternative symbolic domain rich in statistical structure. Specifically, we study the Evo2 genomic model, trained predominantly on next-nucleotide (A/T/C/G) prediction, at a scale comparable to mid-sized LLMs. We develop a controlled experimental framework comprising symbolic reasoning tasks instantiated in both linguistic and genomic forms, enabling direct comparison of ICL across genomic and linguistic models. Our results show that genomic models, like their linguistic counterparts, exhibit log-linear gains in pattern induction as the number of in-context demonstrations increases. To the best of our knowledge, this is the first evidence of organically emergent ICL in genomic sequences, supporting the hypothesis that ICL arises as a consequence of large-scale predictive modeling over rich data. These findings extend emergent meta-learning beyond language, pointing toward a unified, modality-agnostic view of in-context learning.