# From 2D to 3D Without Extra Baggage: Data-Efficient Cancer Detection in Digital Breast Tomosynthesis

arXiv: https://arxiv.org/abs/2511.10597 · HTML: https://mlsanity.com/paper/2511.10597/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 10 of its 32 references that are in the map.
- First posted on arXiv 13 Nov 2025.

## Builds on (most cited first, 10 of 10)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Microsoft COCO: Common Objects in Context](https://mlsanity.com/paper/1405.0312/) (2014)
- [Is Space-Time Attention All You Need for Video Understanding?](https://mlsanity.com/paper/2102.05095/) (2021)
- [Sparse R-CNN: End-to-End Object Detection with Learnable Proposals](https://mlsanity.com/paper/2011.12450/) (2020)
- [Detection of masses and architectural distortions in digital breast tomosynthesis: a publicly available dataset of 5,060 patients and a deep learning model](https://mlsanity.com/paper/2011.07995/) (2020)
- [NMS-Loss: Learning with Non-Maximum Suppression for Crowded Pedestrian Detection](https://mlsanity.com/paper/2106.02426/) (2021)
- [Adaptation of a deep learning malignancy model from full-field digital mammography to digital breast tomosynthesis](https://mlsanity.com/paper/2001.08381/) (2020)
- [M&M: Tackling False Positives in Mammography with a Multi-view and Multi-instance Learning Sparse Detector](https://mlsanity.com/paper/2308.06420/) (2023)
- [SIFT-DBT: Self-supervised Initialization and Fine-Tuning for Imbalanced Digital Breast Tomosynthesis Image Classification](https://mlsanity.com/paper/2403.13148/) (2024)
- [CoMoTo: Unpaired Cross-Modal Lesion Distillation Improves Breast Lesion Detection in Tomosynthesis](https://mlsanity.com/paper/2407.17620/) (2024)

## Abstract (arXiv)

Digital Breast Tomosynthesis (DBT) enhances finding visibility for breast cancer detection by providing volumetric information that reduces the impact of overlapping tissues; however, limited annotated data has constrained the development of deep learning models for DBT. To address data scarcity, existing methods attempt to reuse 2D full-field digital mammography (FFDM) models by either flattening DBT volumes or processing slices individually, thus discarding volumetric information. Alternatively, 3D reasoning approaches introduce complex architectures that require more DBT training data. Tackling these drawbacks, we propose M&M-3D, an architecture that enables learnable 3D reasoning while remaining parameter-free relative to its FFDM counterpart, M&M. M&M-3D constructs malignancy-guided 3D features, and 3D reasoning is learned through repeatedly mixing these 3D features with slice-level information. This is achieved by modifying operations in M&M without adding parameters, thus enabling direct weight transfer from FFDM. Extensive experiments show that M&M-3D surpasses 2D projection and 3D slice-based methods by 11-54% for localization and 3-10% for classification. Additionally, M&M-3D outperforms complex 3D reasoning variants by 20-47% for localization and 2-10% for classification in the low-data regime, while matching their performance in high-data regime. On the popular BCS-DBT benchmark, M&M-3D outperforms previous top baseline by 4% for classification and 10% for localization.