# Cross-Modal Fine-Tuning of 3D Convolutional Foundation Models for ADHD Classification with Low-Rank Adaptation

arXiv: https://arxiv.org/abs/2511.06163 · HTML: https://mlsanity.com/paper/2511.06163/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 6 of its 19 references that are in the map.
- First posted on arXiv 8 Nov 2025.

## Builds on (most cited first, 6 of 6)

- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Can Spatiotemporal 3D CNNs Retrace the History of 2D CNNs and ImageNet?](https://mlsanity.com/paper/1711.09577/) (2017)
- [Med3D: Transfer Learning for 3D Medical Image Analysis](https://mlsanity.com/paper/1904.00625/) (2019)
- [Customized Segment Anything Model for Medical Image Segmentation](https://mlsanity.com/paper/2304.13785/) (2023)
- [Models Genesis](https://mlsanity.com/paper/2004.07882/) (2020)

## Abstract (arXiv)

Early diagnosis of attention-deficit/hyperactivity disorder (ADHD) in children plays a crucial role in improving outcomes in education and mental health. Diagnosing ADHD using neuroimaging data, however, remains challenging due to heterogeneous presentations and overlapping symptoms with other conditions. To address this, we propose a novel parameter-efficient transfer learning approach that adapts a large-scale 3D convolutional foundation model, pre-trained on CT images, to an MRI-based ADHD classification task. Our method introduces Low-Rank Adaptation (LoRA) in 3D by factorizing 3D convolutional kernels into 2D low-rank updates, dramatically reducing trainable parameters while achieving superior performance. In a five-fold cross-validated evaluation on a public diffusion MRI database, our 3D LoRA fine-tuning strategy achieved state-of-the-art results, with one model variant reaching 71.9% accuracy and another attaining an AUC of 0.716. Both variants use only 1.64 million trainable parameters (over 113x fewer than a fully fine-tuned foundation model). Our results represent one of the first successful cross-modal (CT-to-MRI) adaptations of a foundation model in neuroimaging, establishing a new benchmark for ADHD classification while greatly improving efficiency.