# BrainCSD: A Hierarchical Consistency-Driven MoE Foundation Model for Unified Connectome Synthesis and Multitask Brain Trait Prediction

arXiv: https://arxiv.org/abs/2511.05630 · HTML: https://mlsanity.com/paper/2511.05630/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical and biomedical MoE, one of 12 directions in Mixture-of-experts.
- Builds on 5 of its 52 references that are in the map.
- First posted on arXiv 7 Nov 2025.

## Placed in

- Mixture-of-experts / [Medical and biomedical MoE](https://mlsanity.com/moe/medical-and-biomedical-moe/)

## Builds on (most cited first, 5 of 5)

- [Learning deep representations by mutual information estimation and maximization](https://mlsanity.com/paper/1808.06670/) (2018)
- [DeepSpeed-MoE: Advancing Mixture-of-Experts Inference and Training to Power Next-Generation AI Scale](https://mlsanity.com/paper/2201.05596/) (2022)
- [Uni-MoE: Scaling Unified Multimodal LLMs with Mixture of Experts](https://mlsanity.com/paper/2405.11273/) (2024)
- [BrainMass: Advancing Brain Network Analysis for Diagnosis with Large-scale Self-Supervised Learning](https://mlsanity.com/paper/2403.01433/) (2024)
- [BrainNet-MoE: Brain-Inspired Mixture-of-Experts Learning for Neurological Disease Identification](https://mlsanity.com/paper/2503.07640/) (2025)

## Abstract (arXiv)

Functional and structural connectivity (FC/SC) are key multimodal biomarkers for brain analysis, yet their clinical utility is hindered by costly acquisition, complex preprocessing, and frequent missing modalities. Existing foundation models either process single modalities or lack explicit mechanisms for cross-modal and cross-scale consistency. We propose BrainCSD, a hierarchical mixture-of-experts (MoE) foundation model that jointly synthesizes FC/SC biomarkers and supports downstream decoding tasks (diagnosis and prediction). BrainCSD features three neuroanatomically grounded components: (1) a ROI-specific MoE that aligns regional activations from canonical networks (e.g., DMN, FPN) with a global atlas via contrastive consistency; (2) a Encoding-Activation MOE that models dynamic cross-time/gradient dependencies in fMRI/dMRI; and (3) a network-aware refinement MoE that enforces structural priors and symmetry at individual and population levels. Evaluated on the datasets under complete and missing-modality settings, BrainCSD achieves SOTA results: 95.6% accuracy for MCI vs. CN classification without FC, low synthesis error (FC RMSE: 0.038; SC RMSE: 0.006), brain age prediction (MAE: 4.04 years), and MMSE score estimation (MAE: 1.72 points). Code is available in hrefhttps://github.com/SXR3015/BrainCSDBrainCSD