# DuetServe: Harmonizing Prefill and Decode for LLM Serving via Adaptive GPU Multiplexing

arXiv: https://arxiv.org/abs/2511.04791 · HTML: https://mlsanity.com/paper/2511.04791/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Placed in Serving systems and request scheduling, one of 12 directions in Efficient LLM inference and serving.
- Builds on 19 of its 46 references that are in the map.
- First posted on arXiv 6 Nov 2025.

## Placed in

- Efficient LLM inference and serving / [Serving systems and request scheduling](https://mlsanity.com/inference/serving-systems-and-request-scheduling/)

## Builds on (most cited first, 19 of 19)

- [Efficient Memory Management for Large Language Model Serving with PagedAttention](https://mlsanity.com/paper/2309.06180/) (2023)
- [FlashAttention: Fast and Memory-Efficient Exact Attention with IO-Awareness](https://mlsanity.com/paper/2205.14135/) (2022)
- [CAMEL: Communicative Agents for "Mind" Exploration of Large Language Model Society](https://mlsanity.com/paper/2303.17760/) (2023)
- [SGLang: Efficient Execution of Structured Language Model Programs](https://mlsanity.com/paper/2312.07104/) (2023)
- [DistServe: Disaggregating Prefill and Decoding for Goodput-optimized Large Language Model Serving](https://mlsanity.com/paper/2401.09670/) (2024)
- [Splitwise: Efficient generative LLM inference using phase splitting](https://mlsanity.com/paper/2311.18677/) (2023)
- [Taming Throughput-Latency Tradeoff in LLM Inference with Sarathi-Serve](https://mlsanity.com/paper/2403.02310/) (2024)
- [FlashAttention-3: Fast and Accurate Attention with Asynchrony and Low-precision](https://mlsanity.com/paper/2407.08608/) (2024)
- [Sora: A Review on Background, Technology, Limitations, and Opportunities of Large Vision Models](https://mlsanity.com/paper/2402.17177/) (2024)
- [Inference without Interference: Disaggregate LLM Inference for Mixed Downstream Workloads](https://mlsanity.com/paper/2401.11181/) (2024)
- [Vidur: A Large-Scale Simulation Framework For LLM Inference](https://mlsanity.com/paper/2405.05465/) (2024)
- [NanoFlow: Towards Optimal Large Language Model Serving Throughput](https://mlsanity.com/paper/2408.12757/) (2024)
- [MemServe: Context Caching for Disaggregated LLM Serving with Elastic Memory Pool](https://mlsanity.com/paper/2406.17565/) (2024)
- [MuxServe: Flexible Spatial-Temporal Multiplexing for Multiple LLM Serving](https://mlsanity.com/paper/2404.02015/) (2024)
- [ASTRA-sim2.0: Modeling Hierarchical Networks and Disaggregated Systems for Large-model Training at Scale](https://mlsanity.com/paper/2303.14006/) (2023)
- [POD-Attention: Unlocking Full Prefill-Decode Overlap for Faster LLM Inference](https://mlsanity.com/paper/2410.18038/) (2024)
- [semi-PD: Towards Efficient LLM Serving via Phase-Wise Disaggregated Computation and Unified Storage](https://mlsanity.com/paper/2504.19867/) (2025)
- [Nexus:Proactive Intra-GPU Disaggregation of Prefill and Decode in LLM Serving](https://mlsanity.com/paper/2507.06608/) (2025)
- [Beyond the Buzz: A Pragmatic Take on Inference Disaggregation](https://mlsanity.com/paper/2506.05508/) (2025)

## Built on by (most cited first, 4 of 4)

- [Observation, Not Prediction: Conversation-Level Disaggregated Scheduling for Agentic Serving](https://mlsanity.com/paper/2606.01839/) (2026)
- [Crossflow: Prefill-Decode Elasticity for Agentic LLM Serving](https://mlsanity.com/paper/2609.27085/) (2026)
- [FlexNPU: Transparent NPU Virtualization for Dynamic LLM Prefill-Decode Co-location](https://mlsanity.com/paper/2606.04415/) (2026)
- [Prorsa: Unleashing the Potential of Prefill-Decode Disaggregation in Agentic Reinforcement Learning](https://mlsanity.com/paper/2610.16592/) (2026)

## Abstract (arXiv)

Modern LLM serving systems must sustain high throughput while meeting strict latency SLOs across two distinct inference phases: compute-intensive prefill and memory-bound decode phases. Existing approaches either (1) aggregate both phases on shared GPUs, leading to interference between prefill and decode phases, which degrades Time-Between-Tokens (TBT); or (2) disaggregate the two phases across GPUs, improving latency but wasting resources through duplicated models and KV cache transfers. We present DuetServe, a unified LLM serving framework that achieves disaggregation-level isolation within a single GPU. DuetServe operates in aggregated mode by default and dynamically activates SM-level GPU spatial multiplexing when TBT degradation is predicted. Its key idea is to decouple prefill and decode execution only when needed through fine-grained, adaptive SM partitioning that provides phase isolation only when contention threatens latency service level objectives. DuetServe integrates (1) an attention-aware roofline model to forecast iteration latency, (2) a partitioning optimizer that selects the optimal SM split to maximize throughput under TBT constraints, and (3) an interruption-free execution engine that eliminates CPU-GPU synchronization overhead. Evaluations show that DuetServe improves total throughput by up to 1.3x while maintaining low generation latency compared to state-of-the-art frameworks.