# Computational Imaging Meets LLMs: Zero-Shot IDH Mutation Prediction in Brain Gliomas

arXiv: https://arxiv.org/abs/2511.03376 · HTML: https://mlsanity.com/paper/2511.03376/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 3 of its 28 references that are in the map.
- First posted on arXiv 5 Nov 2025.

## Builds on (most cited first, 3 of 3)

- [The RSNA-ASNR-MICCAI BraTS 2021 Benchmark on Brain Tumor Segmentation and Radiogenomic Classification](https://mlsanity.com/paper/2107.02314/) (2021)
- [The University of California San Francisco Preoperative Diffuse Glioma MRI (UCSF-PDGM) Dataset](https://mlsanity.com/paper/2109.00356/) (2021)
- [BrainSegFounder: Towards 3D Foundation Models for Neuroimage Segmentation](https://mlsanity.com/paper/2406.10395/) (2024)

## Abstract (arXiv)

We present a framework that combines Large Language Models with computational image analytics for non-invasive, zero-shot prediction of IDH mutation status in brain gliomas. For each subject, coregistered multi-parametric MRI scans and multi-class tumor segmentation maps were processed to extract interpretable semantic (visual) attributes and quantitative features, serialized in a standardized JSON file, and used to query GPT 4o and GPT 5 without fine-tuning. We evaluated this framework on six publicly available datasets (N = 1427) and results showcased high accuracy and balanced classification performance across heterogeneous cohorts, even in the absence of manual annotations. GPT 5 outperformed GPT 4o in context-driven phenotype interpretation. Volumetric features emerged as the most important predictors, supplemented by subtype-specific imaging markers and clinical information. Our results demonstrate the potential of integrating LLM-based reasoning with computational image analytics for precise, non-invasive tumor genotyping, advancing diagnostic strategies in neuro-oncology. The code is available at https://github.com/ATPLab-LUMS/CIM-LLM.