# Domain-Adaptive Transformer for Data-Efficient Glioma Segmentation in Sub-Saharan MRI

arXiv: https://arxiv.org/abs/2511.02928 · HTML: https://mlsanity.com/paper/2511.02928/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 7 of its 18 references that are in the map.
- First posted on arXiv 4 Nov 2025.

## Builds on (most cited first, 7 of 7)

- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [SegFormer: Simple and Efficient Design for Semantic Segmentation with Transformers](https://mlsanity.com/paper/2105.15203/) (2021)
- [CBAM: Convolutional Block Attention Module](https://mlsanity.com/paper/1807.06521/) (2018)
- [Swin-Unet: Unet-like Pure Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2105.05537/) (2021)
- [Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS Challenge](https://mlsanity.com/paper/1811.02629/) (2018)
- [Transfusion: Understanding Transfer Learning for Medical Imaging](https://mlsanity.com/paper/1902.07208/) (2019)
- [VM-UNet: Vision Mamba UNet for Medical Image Segmentation](https://mlsanity.com/paper/2402.02491/) (2024)

## Abstract (arXiv)

Glioma segmentation is critical for diagnosis and treatment planning, yet remains challenging in Sub-Saharan Africa due to limited MRI infrastructure and heterogeneous acquisition protocols that induce severe domain shift. We propose SegFormer3D-plus, a radiomics-guided transformer architecture designed for robust segmentation under domain variability. Our method combines: (1) histogram matching for intensity harmonization across scanners, (2) radiomic feature extraction with PCA-reduced k-means for domain-aware stratified sampling, (3) a dual-pathway encoder with frequency-aware feature extraction and spatial-channel attention, and (4) composite Dice-Cross-Entropy loss for boundary refinement. Pretrained on BraTS 2023 and fine-tuned on BraTS-Africa data, SegFormer3D-plus demonstrates improved tumor subregion delineation and boundary localization across heterogeneous African clinical scans, highlighting the value of radiomics-guided domain adaptation for resource-limited settings.