# CMI-MTL: Cross-Mamba interaction based multi-task learning for medical visual question answering

arXiv: https://arxiv.org/abs/2511.01357 · HTML: https://mlsanity.com/paper/2511.01357/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Vision Mamba backbones, one of 10 directions in State-space sequence models (S4, Mamba).
- Builds on 23 of its 43 references that are in the map.
- First posted on arXiv 3 Nov 2025.

## Placed in

- State-space sequence models (S4, Mamba) / [Vision Mamba backbones](https://mlsanity.com/ssm/vision-mamba-backbones/)

## Builds on (most cited first, 23 of 23)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [RoBERTa: A Robustly Optimized BERT Pretraining Approach](https://mlsanity.com/paper/1907.11692/) (2019)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [BLIP-2: Bootstrapping Language-Image Pre-training with Frozen Image Encoders and Large Language Models](https://mlsanity.com/paper/2301.12597/) (2023)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [Flamingo: a Visual Language Model for Few-Shot Learning](https://mlsanity.com/paper/2204.14198/) (2022)
- [SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answering](https://mlsanity.com/paper/2102.09542/) (2021)
- [Medical Visual Question Answering: A Survey](https://mlsanity.com/paper/2111.10056/) (2021)
- [Pan-Mamba: Effective pan-sharpening with State Space Model](https://mlsanity.com/paper/2402.12192/) (2024)
- [Overcoming Data Limitation in Medical Visual Question Answering](https://mlsanity.com/paper/1909.11867/) (2019)
- [MMBERT: Multimodal BERT Pretraining for Improved Medical VQA](https://mlsanity.com/paper/2104.01394/) (2021)
- [Fusion-Mamba for Cross-modality Object Detection](https://mlsanity.com/paper/2404.09146/) (2024)
- [Surgical-VQA: Visual Question Answering in Surgical Scenes using Transformer](https://mlsanity.com/paper/2206.11053/) (2022)
- [Open-Ended Medical Visual Question Answering Through Prefix Tuning of Language Models](https://mlsanity.com/paper/2303.05977/) (2023)
- [Multiple Meta-model Quantifying for Medical Visual Question Answering](https://mlsanity.com/paper/2105.08913/) (2021)
- [MambaDFuse: A Mamba-based Dual-phase Model for Multi-modality Image Fusion](https://mlsanity.com/paper/2404.08406/) (2024)
- [Self-supervised vision-language pretraining for Medical visual question answering](https://mlsanity.com/paper/2211.13594/) (2022)
- [Masked Vision and Language Pre-training with Unimodal and Multimodal Contrastive Losses for Medical Visual Question Answering](https://mlsanity.com/paper/2307.05314/) (2023)
- [LaPA: Latent Prompt Assist Model For Medical Visual Question Answering](https://mlsanity.com/paper/2404.13039/) (2024)
- [Topicwise Separable Sentence Retrieval for Medical Report Generation](https://mlsanity.com/paper/2405.04175/) (2024)
- [3DStyleGLIP: Part-Tailored Text-Guided 3D Neural Stylization](https://mlsanity.com/paper/2404.02634/) (2024)

## Abstract (arXiv)

Medical visual question answering (Med-VQA) is a crucial multimodal task in clinical decision support and telemedicine. Recent self-attention based methods struggle to effectively handle cross-modal semantic alignments between vision and language. Moreover, classification-based methods rely on predefined answer sets. Treating this task as a simple classification problem may make it unable to adapt to the diversity of free-form answers and overlook the detailed semantic information of free-form answers. In order to tackle these challenges, we introduce a Cross-Mamba Interaction based Multi-Task Learning (CMI-MTL) framework that learns cross-modal feature representations from images and texts. CMI-MTL comprises three key modules: fine-grained visual-text feature alignment (FVTA), cross-modal interleaved feature representation (CIFR), and free-form answer-enhanced multi-task learning (FFAE). FVTA extracts the most relevant regions in image-text pairs through fine-grained visual-text feature alignment. CIFR captures cross-modal sequential interactions via cross-modal interleaved feature representation. FFAE leverages auxiliary knowledge from open-ended questions through free-form answer-enhanced multi-task learning, improving the model's capability for open-ended Med-VQA. Experimental results show that CMI-MTL outperforms the existing state-of-the-art methods on three Med-VQA datasets: VQA-RAD, SLAKE, and OVQA. Furthermore, we conduct more interpretability experiments to prove the effectiveness. The code is publicly available at https://github.com/BioMedIA-repo/CMI-MTL.