# Positive Semi-definite Latent Factor Grouping-Boosted Cluster-reasoning Instance Disentangled Learning for WSI Representation

arXiv: https://arxiv.org/abs/2511.01304 · HTML: https://mlsanity.com/paper/2511.01304/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 22 of its 37 references that are in the map.
- First posted on arXiv 3 Nov 2025.

## Builds on (most cited first, 22 of 22)

- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Deep Sets](https://mlsanity.com/paper/1703.06114/) (2017)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [Deep Clustering for Unsupervised Learning of Visual Features](https://mlsanity.com/paper/1807.05520/) (2018)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2106.00908/) (2021)
- [Dual-stream Multiple Instance Learning Network for Whole Slide Image Classification with Self-supervised Contrastive Learning](https://mlsanity.com/paper/2011.08939/) (2020)
- [DTFD-MIL: Double-Tier Feature Distillation Multiple Instance Learning for Histopathology Whole Slide Image Classification](https://mlsanity.com/paper/2203.12081/) (2022)
- [Deep Structural Causal Models for Tractable Counterfactual Inference](https://mlsanity.com/paper/2006.06485/) (2020)
- [Unsupervised Domain Adaptation via Structurally Regularized Deep Clustering](https://mlsanity.com/paper/2003.08607/) (2020)
- [Disentangled Representation Learning](https://mlsanity.com/paper/2211.11695/) (2022)
- [Interventional Bag Multi-Instance Learning On Whole-Slide Pathological Images](https://mlsanity.com/paper/2303.06873/) (2023)
- [Morphological Prototyping for Unsupervised Slide Representation Learning in Computational Pathology](https://mlsanity.com/paper/2405.11643/) (2024)
- [Feature Re-Embedding: Towards Foundation Model-Level Performance in Computational Pathology](https://mlsanity.com/paper/2402.17228/) (2024)
- [Attention-Challenging Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2311.07125/) (2023)
- [Pathologist-level classification of histologic patterns on resected lung adenocarcinoma slides with deep neural networks](https://mlsanity.com/paper/1901.11489/) (2019)
- [Structured State Space Models for Multiple Instance Learning in Digital Pathology](https://mlsanity.com/paper/2306.15789/) (2023)
- [Deep Incomplete Multi-view Clustering with Cross-view Partial Sample and Prototype Alignment](https://mlsanity.com/paper/2303.15689/) (2023)
- [GCFAgg: Global and Cross-view Feature Aggregation for Multi-view Clustering](https://mlsanity.com/paper/2305.06799/) (2023)
- [DGR-MIL: Exploring Diverse Global Representation in Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2407.03575/) (2024)
- [cDP-MIL: Robust Multiple Instance Learning via Cascaded Dirichlet Process](https://mlsanity.com/paper/2407.11448/) (2024)
- [Establishing Causal Relationship Between Whole Slide Image Predictions and Diagnostic Evidence Subregions in Deep Learning](https://mlsanity.com/paper/2407.17157/) (2024)

## Abstract (arXiv)

Multiple instance learning (MIL) has been widely used for representing whole-slide pathology images. However, spatial, semantic, and decision entanglements among instances limit its representation and interpretability. To address these challenges, we propose a latent factor grouping-boosted cluster-reasoning instance disentangled learning framework for whole-slide image (WSI) interpretable representation in three phases. First, we introduce a novel positive semi-definite latent factor grouping that maps instances into a latent subspace, effectively mitigating spatial entanglement in MIL. To alleviate semantic entanglement, we employs instance probability counterfactual inference and optimization via cluster-reasoning instance disentangling. Finally, we employ a generalized linear weighted decision via instance effect re-weighting to address decision entanglement. Extensive experiments on multicentre datasets demonstrate that our model outperforms all state-of-the-art models. Moreover, it attains pathologist-aligned interpretability through disentangled representations and a transparent decision-making process.