# Deep Generative Models for Enhanced Vitreous OCT Imaging

arXiv: https://arxiv.org/abs/2511.00881 · HTML: https://mlsanity.com/paper/2511.00881/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 23 of its 53 references that are in the map.
- First posted on arXiv 2 Nov 2025.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 23 of 23)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Improved Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2102.09672/) (2021)
- [Palette: Image-to-Image Diffusion Models](https://mlsanity.com/paper/2111.05826/) (2021)
- [Vector-quantized Image Modeling with Improved VQGAN](https://mlsanity.com/paper/2110.04627/) (2021)
- [MaskGAN: Towards Diverse and Interactive Facial Image Manipulation](https://mlsanity.com/paper/1907.11922/) (2019)
- [Diffusion Models for Medical Anomaly Detection](https://mlsanity.com/paper/2203.04306/) (2022)
- [BBDM: Image-to-image Translation with Brownian Bridge Diffusion Models](https://mlsanity.com/paper/2205.07680/) (2022)
- [Diffusion Models for Implicit Image Segmentation Ensembles](https://mlsanity.com/paper/2112.03145/) (2021)
- [How to Fool Radiologists with Generative Adversarial Networks? A Visual Turing Test for Lung Cancer Diagnosis](https://mlsanity.com/paper/1710.09762/) (2017)
- [Diffusion Models for Contrast Harmonization of Magnetic Resonance Images](https://mlsanity.com/paper/2303.08189/) (2023)
- [Deep Generative Models for 3D Medical Image Synthesis](https://mlsanity.com/paper/2410.17664/) (2024)
- [Denoising Diffusion Models for Inpainting of Healthy Brain Tissue](https://mlsanity.com/paper/2402.17307/) (2024)
- [EBDM: Exemplar-guided Image Translation with Brownian-bridge Diffusion Models](https://mlsanity.com/paper/2410.09802/) (2024)
- [fastWDM3D: Fast and Accurate 3D Healthy Tissue Inpainting](https://mlsanity.com/paper/2507.13146/) (2025)
- [Content-Preserving Diffusion Model for Unsupervised AS-OCT image Despeckling](https://mlsanity.com/paper/2306.17717/) (2023)
- [Conditioning 3D Diffusion Models with 2D Images: Towards Standardized OCT Volumes through En Face-Informed Super-Resolution](https://mlsanity.com/paper/2410.09862/) (2024)

## Abstract (arXiv)

Purpose: To evaluate deep learning (DL) models for enhancing vitreous optical coherence tomography (OCT) image quality and reducing acquisition time. Methods: Conditional Denoising Diffusion Probabilistic Models (cDDPMs), Brownian Bridge Diffusion Models (BBDMs), U-Net, Pix2Pix, and Vector-Quantised Generative Adversarial Network (VQ-GAN) were used to generate high-quality spectral-domain (SD) vitreous OCT images. Inputs were SD ART10 images, and outputs were compared to pseudoART100 images obtained by averaging ten ART10 images per eye location. Model performance was assessed using image quality metrics and Visual Turing Tests, where ophthalmologists ranked generated images and evaluated anatomical fidelity. The best model's performance was further tested within the manually segmented vitreous on newly acquired data. Results: U-Net achieved the highest Peak Signal-to-Noise Ratio (PSNR: 30.230) and Structural Similarity Index Measure (SSIM: 0.820), followed by cDDPM. For Learned Perceptual Image Patch Similarity (LPIPS), Pix2Pix (0.697) and cDDPM (0.753) performed best. In the first Visual Turing Test, cDDPM ranked highest (3.07); in the second (best model only), cDDPM achieved a 32.9% fool rate and 85.7% anatomical preservation. On newly acquired data, cDDPM generated vitreous regions more similar in PSNR to the ART100 reference than true ART1 or ART10 B-scans and achieved higher PSNR on whole images when conditioned on ART1 than ART10. Conclusions: Results reveal discrepancies between quantitative metrics and clinical evaluation, highlighting the need for combined assessment. cDDPM showed strong potential for generating clinically meaningful vitreous OCT images while reducing acquisition time fourfold. Translational Relevance: cDDPMs show promise for clinical integration, supporting faster, higher-quality vitreous imaging. Dataset and code will be made publicly available.