# Towards Reliable Pediatric Brain Tumor Segmentation: Task-Specific nnU-Net Enhancements

arXiv: https://arxiv.org/abs/2511.00449 · HTML: https://mlsanity.com/paper/2511.00449/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 12 of its 14 references that are in the map.
- First posted on arXiv 1 Nov 2025.

## Builds on (most cited first, 12 of 12)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Squeeze-and-Excitation Networks](https://mlsanity.com/paper/1709.01507/) (2017)
- [MobileNets: Efficient Convolutional Neural Networks for Mobile Vision Applications](https://mlsanity.com/paper/1704.04861/) (2017)
- [Frequency Principle: Fourier Analysis Sheds Light on Deep Neural Networks](https://mlsanity.com/paper/1901.06523/) (2019)
- [MedPerf: Open Benchmarking Platform for Medical Artificial Intelligence using Federated Evaluation](https://mlsanity.com/paper/2110.01406/) (2021)
- [Phase diagram for two-layer ReLU neural networks at infinite-width limit](https://mlsanity.com/paper/2007.07497/) (2020)
- [The Brain Tumor Segmentation (BraTS) Challenge 2023: Focus on Pediatrics (CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs)](https://mlsanity.com/paper/2305.17033/) (2023)
- [Primus: Enforcing Attention Usage for 3D Medical Image Segmentation](https://mlsanity.com/paper/2503.01835/) (2025)
- [Loss Spike in Training Neural Networks](https://mlsanity.com/paper/2305.12133/) (2023)
- [The Brain Tumor Segmentation in Pediatrics (BraTS-PEDs) Challenge: Focus on Pediatrics (CBTN-CONNECT-DIPGR-ASNR-MICCAI BraTS-PEDs)](https://mlsanity.com/paper/2404.15009/) (2024)
- [Scalable Complexity Control Facilitates Reasoning Ability of LLMs](https://mlsanity.com/paper/2505.23013/) (2025)

## Abstract (arXiv)

Accurate segmentation of pediatric brain tumors in multi-parametric magnetic resonance imaging (mpMRI) is critical for diagnosis, treatment planning, and monitoring, yet faces unique challenges due to limited data, high anatomical variability, and heterogeneous imaging across institutions. In this work, we present an advanced nnU-Net framework tailored for BraTS 2025 Task-6 (PED), the largest public dataset of pre-treatment pediatric high-grade gliomas. Our contributions include: (1) a widened residual encoder with squeeze-and-excitation (SE) attention; (2) 3D depthwise separable convolutions; (3) a specificity-driven regularization term; and (4) small-scale Gaussian weight initialization. We further refine predictions with two postprocessing steps. Our models achieved first place on the Task-6 validation leaderboard, attaining lesion-wise Dice scores of 0.759 (CC), 0.967 (ED), 0.826 (ET), 0.910 (NET), 0.928 (TC) and 0.928 (WT).