# Beyond Data Scarcity Optimizing R3GAN for Medical Image Generation from Small Datasets

arXiv: https://arxiv.org/abs/2510.26828 · HTML: https://mlsanity.com/paper/2510.26828/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 13 of its 24 references that are in the map.
- First posted on arXiv 29 Oct 2025.

## Builds on (most cited first, 13 of 13)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [mixup: Beyond Empirical Risk Minimization](https://mlsanity.com/paper/1710.09412/) (2017)
- [CutMix: Regularization Strategy to Train Strong Classifiers with Localizable Features](https://mlsanity.com/paper/1905.04899/) (2019)
- [Conditional Generative Adversarial Nets](https://mlsanity.com/paper/1411.1784/) (2014)
- [Unsupervised Representation Learning with Deep Convolutional Generative Adversarial Networks](https://mlsanity.com/paper/1511.06434/) (2015)
- [Which Training Methods for GANs do actually Converge?](https://mlsanity.com/paper/1801.04406/) (2018)
- [The relativistic discriminator: a key element missing from standard GAN](https://mlsanity.com/paper/1807.00734/) (2018)
- [Stabilizing Training of Generative Adversarial Networks through Regularization](https://mlsanity.com/paper/1705.09367/) (2017)
- [The GAN is dead; long live the GAN! A Modern GAN Baseline](https://mlsanity.com/paper/2501.05441/) (2025)

## Built on by (most cited first, 1 of 1)

- [BioVid: Autoregressive Video Generation with Biological Behavior Semantic Comprehension](https://mlsanity.com/paper/2606.08674/) (2026)

## Abstract (arXiv)

Medical image datasets frequently exhibit significant class imbalance, a challenge that is further amplified by the inherently limited sample sizes that characterize clinical imaging data. Using human embryo time-lapse imaging (TLI) as a case study, this work investigates how generative adversarial networks (GANs) can be optimized for small datasets to generate realistic and diagnostically meaningful images. Based on systematic experiments with R3GAN, we established effective training strategies and designed an optimized configuration for 256x256-resolution datasets, featuring a full burn-in phase and a low, gradually increasing gamma range (5 to 40). The generated samples were used to balance an imbalanced embryo dataset, leading to substantial improvement in classification performance. The recall and F1-score of the three-cell (t3) class increased from 0.06 to 0.69 and from 0.11 to 0.60, respectively, without compromising the performance of other classes. These results demonstrate that tailored R3GAN training strategies can effectively alleviate data scarcity and improve model robustness in small-scale medical imaging tasks.