# Leveraging LLMs for Early Alzheimer's Prediction

arXiv: https://arxiv.org/abs/2510.23946 · HTML: https://mlsanity.com/paper/2510.23946/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 7 of its 24 references that are in the map.
- First posted on arXiv 27 Oct 2025.

## Builds on (most cited first, 7 of 7)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [A Time Series is Worth 64 Words: Long-term Forecasting with Transformers](https://mlsanity.com/paper/2211.14730/) (2022)
- [Time-LLM: Time Series Forecasting by Reprogramming Large Language Models](https://mlsanity.com/paper/2310.01728/) (2023)
- [Topological Learning for Brain Networks](https://mlsanity.com/paper/2012.00675/) (2020)
- [Augmenting Bias Detection in LLMs Using Topological Data Analysis](https://mlsanity.com/paper/2508.07516/) (2025)

## Abstract (arXiv)

We present a connectome-informed LLM framework that encodes dynamic fMRI connectivity as temporal sequences, applies robust normalization, and maps these data into a representation suitable for a frozen pre-trained LLM for clinical prediction. Applied to early Alzheimer's detection, our method achieves sensitive prediction with error rates well below clinically recognized margins, with implications for timely Alzheimer's intervention.