# PSScreen V2: Partially Supervised Multiple Retinal Disease Screening

arXiv: https://arxiv.org/abs/2510.22589 · HTML: https://mlsanity.com/paper/2510.22589/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 33 of its 59 references that are in the map.
- First posted on arXiv 26 Oct 2025.

## Builds on (most cited first, 30 of 33)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Arbitrary Style Transfer in Real-time with Adaptive Instance Normalization](https://mlsanity.com/paper/1703.06868/) (2017)
- [CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparison](https://mlsanity.com/paper/1901.07031/) (2019)
- [Learning Transferable Features with Deep Adaptation Networks](https://mlsanity.com/paper/1502.02791/) (2015)
- [Interpretability Beyond Feature Attribution: Quantitative Testing with Concept Activation Vectors (TCAV)](https://mlsanity.com/paper/1711.11279/) (2017)
- [Publicly Available Clinical BERT Embeddings](https://mlsanity.com/paper/1904.03323/) (2019)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)
- [FDA: Fourier Domain Adaptation for Semantic Segmentation](https://mlsanity.com/paper/2004.05498/) (2020)
- [BiomedCLIP: a multimodal biomedical foundation model pretrained from fifteen million scientific image-text pairs](https://mlsanity.com/paper/2303.00915/) (2023)
- [Learning a Deep ConvNet for Multi-label Classification with Partial Labels](https://mlsanity.com/paper/1902.09720/) (2019)
- [Learning Semantic-Specific Graph Representation for Multi-Label Image Recognition](https://mlsanity.com/paper/1908.07325/) (2019)
- [A Foundation Language-Image Model of the Retina (FLAIR): Encoding Expert Knowledge in Text Supervision](https://mlsanity.com/paper/2308.07898/) (2023)
- [Structured Semantic Transfer for Multi-Label Recognition with Partial Labels](https://mlsanity.com/paper/2112.10941/) (2021)
- [REFUGE2 Challenge: A Treasure Trove for Multi-Dimension Analysis and Evaluation in Glaucoma Screening](https://mlsanity.com/paper/2202.08994/) (2022)
- [A Benchmark of Ocular Disease Intelligent Recognition: One Shot for Multi-disease Detection](https://mlsanity.com/paper/2102.07978/) (2021)
- [RET-CLIP: A Retinal Image Foundation Model Pre-trained with Clinical Diagnostic Reports](https://mlsanity.com/paper/2405.14137/) (2024)
- [Semantic-Aware Representation Blending for Multi-Label Image Recognition with Partial Labels](https://mlsanity.com/paper/2203.02172/) (2022)
- [ALOFT: A Lightweight MLP-like Architecture with Dynamic Low-frequency Transform for Domain Generalization](https://mlsanity.com/paper/2303.11674/) (2023)
- [ADAM Challenge: Detecting Age-related Macular Degeneration from Fundus Images](https://mlsanity.com/paper/2202.07983/) (2022)
- [SoMA: Singular Value Decomposed Minor Components Adaptation for Domain Generalizable Representation Learning](https://mlsanity.com/paper/2412.04077/) (2024)
- [Heterogeneous Semantic Transfer for Multi-label Recognition with Partial Labels](https://mlsanity.com/paper/2205.11131/) (2022)
- [Multi-Label Retinal Disease Classification using Transformers](https://mlsanity.com/paper/2207.02335/) (2022)
- [Adversarial Style Augmentation for Domain Generalization](https://mlsanity.com/paper/2301.12643/) (2023)
- [BiRA-Net: Bilinear Attention Net for Diabetic Retinopathy Grading](https://mlsanity.com/paper/1905.06312/) (2019)
- [PALM: Open Fundus Photograph Dataset with Pathologic Myopia Recognition and Anatomical Structure Annotation](https://mlsanity.com/paper/2305.07816/) (2023)
- [Hierarchical Knowledge Guided Learning for Real-world Retinal Diseases Recognition](https://mlsanity.com/paper/2111.08913/) (2021)

## Abstract (arXiv)

In this work, we propose PSScreen V2, a partially supervised self-training framework for multiple retinal disease screening. Unlike previous methods that rely on fully labelled or single-domain datasets, PSScreen V2 is designed to learn from multiple partially labelled datasets with different distributions, addressing both label absence and domain shift challenges. To this end, PSScreen V2 adopts a three-branch architecture with one teacher and two student networks. The teacher branch generates pseudo labels from weakly augmented images to address missing labels, while the two student branches introduce novel feature augmentation strategies: Low-Frequency Dropout (LF-Dropout), which enhances domain robustness by randomly discarding domain-related low-frequency components, and Low-Frequency Uncertainty (LF-Uncert), which estimates uncertain domain variability via adversarially learned Gaussian perturbations of low-frequency statistics. Extensive experiments on multiple in-domain and out-of-domain fundus datasets demonstrate that PSScreen V2 achieves state-of-the-art performance and superior domain generalization ability. Furthermore, compatibility tests with diverse backbones, including the vision foundation model DINOv2, as well as evaluations on chest X-ray datasets, highlight the universality and adaptability of the proposed framework. The codes are available at https://github.com/boyiZheng99/PSScreen_V2.