# From Pixels to Views: Learning Angular-Aware and Physics-Consistent Representations for Light Field Microscopy

arXiv: https://arxiv.org/abs/2510.22577 · HTML: https://mlsanity.com/paper/2510.22577/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 19 of its 40 references that are in the map.
- First posted on arXiv 26 Oct 2025.

## Builds on (most cited first, 19 of 19)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
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- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [A ConvNet for the 2020s](https://mlsanity.com/paper/2201.03545/) (2022)
- [Supervised Contrastive Learning](https://mlsanity.com/paper/2004.11362/) (2020)
- [Pyramid Vision Transformer: A Versatile Backbone for Dense Prediction without Convolutions](https://mlsanity.com/paper/2102.12122/) (2021)
- [What Makes for Good Views for Contrastive Learning?](https://mlsanity.com/paper/2005.10243/) (2020)
- [Debiased Contrastive Learning](https://mlsanity.com/paper/2007.00224/) (2020)
- [Parametric Contrastive Learning](https://mlsanity.com/paper/2107.12028/) (2021)
- [Behavior From the Void: Unsupervised Active Pre-Training](https://mlsanity.com/paper/2103.04551/) (2021)
- [Contrastive Learning with Stronger Augmentations](https://mlsanity.com/paper/2104.07713/) (2021)
- [Unsupervised Pre-training for Person Re-identification](https://mlsanity.com/paper/2012.03753/) (2020)
- [DETReg: Unsupervised Pretraining with Region Priors for Object Detection](https://mlsanity.com/paper/2106.04550/) (2021)
- [FourierNets enable the design of highly non-local optical encoders for computational imaging](https://mlsanity.com/paper/2104.10611/) (2021)
- [Fast light-field 3D microscopy with out-of-distribution detection and adaptation through Conditional Normalizing Flows](https://mlsanity.com/paper/2306.06408/) (2023)

## Abstract (arXiv)

Light field microscopy (LFM) has become an emerging tool in neuroscience for large-scale neural imaging in vivo, notable for its single-exposure volumetric imaging, broad field of view, and high temporal resolution. However, learning-based 3D reconstruction in XLFM remains underdeveloped due to two core challenges: the absence of standardized datasets and the lack of methods that can efficiently model its angular-spatial structure while remaining physically grounded. We address these challenges by introducing three key contributions. First, we construct the XLFM-Zebrafish benchmark, a large-scale dataset and evaluation suite for XLFM reconstruction. Second, we propose Masked View Modeling for Light Fields (MVN-LF), a self-supervised task that learns angular priors by predicting occluded views, improving data efficiency. Third, we formulate the Optical Rendering Consistency Loss (ORC Loss), a differentiable rendering constraint that enforces alignment between predicted volumes and their PSF-based forward projections. On the XLFM-Zebrafish benchmark, our method improves PSNR by 7.7% over state-of-the-art baselines.