# ITC-RWKV: Interactive Tissue-Cell Modeling with Recurrent Key-Value Aggregation for Histopathological Subtyping

arXiv: https://arxiv.org/abs/2510.21479 · HTML: https://mlsanity.com/paper/2510.21479/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 31 of its 43 references that are in the map.
- First posted on arXiv 24 Oct 2025.

## Builds on (most cited first, 30 of 31)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Deep Sets](https://mlsanity.com/paper/1703.06114/) (2017)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [RWKV: Reinventing RNNs for the Transformer Era](https://mlsanity.com/paper/2305.13048/) (2023)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2106.00908/) (2021)
- [Dual-stream Multiple Instance Learning Network for Whole Slide Image Classification with Self-supervised Contrastive Learning](https://mlsanity.com/paper/2011.08939/) (2020)
- [HoVer-Net: Simultaneous Segmentation and Classification of Nuclei in Multi-Tissue Histology Images](https://mlsanity.com/paper/1812.06499/) (2018)
- [Whole Slide Images based Cancer Survival Prediction using Attention Guided Deep Multiple Instance Learning Networks](https://mlsanity.com/paper/2009.11169/) (2020)
- [Self supervised contrastive learning for digital histopathology](https://mlsanity.com/paper/2011.13971/) (2020)
- [BRACS: A Dataset for BReAst Carcinoma Subtyping in H&E Histology Images](https://mlsanity.com/paper/2111.04740/) (2021)
- [BACH: Grand Challenge on Breast Cancer Histology Images](https://mlsanity.com/paper/1808.04277/) (2018)
- [Whole Slide Images are 2D Point Clouds: Context-Aware Survival Prediction using Patch-based Graph Convolutional Networks](https://mlsanity.com/paper/2107.13048/) (2021)
- [PanNuke Dataset Extension, Insights and Baselines](https://mlsanity.com/paper/2003.10778/) (2020)
- [CellViT: Vision Transformers for Precise Cell Segmentation and Classification](https://mlsanity.com/paper/2306.15350/) (2023)
- [Vision-RWKV: Efficient and Scalable Visual Perception with RWKV-Like Architectures](https://mlsanity.com/paper/2403.02308/) (2024)
- [Self-Path: Self-supervision for Classification of Pathology Images with Limited Annotations](https://mlsanity.com/paper/2008.05571/) (2020)
- [Hierarchical Graph Representations in Digital Pathology](https://mlsanity.com/paper/2102.11057/) (2021)
- [CGC-Net: Cell Graph Convolutional Network for Grading of Colorectal Cancer Histology Images](https://mlsanity.com/paper/1909.01068/) (2019)
- [Diffusion-RWKV: Scaling RWKV-Like Architectures for Diffusion Models](https://mlsanity.com/paper/2404.04478/) (2024)
- [HACT-Net: A Hierarchical Cell-to-Tissue Graph Neural Network for Histopathological Image Classification](https://mlsanity.com/paper/2007.00584/) (2020)
- [Towards A Generalizable Pathology Foundation Model via Unified Knowledge Distillation](https://mlsanity.com/paper/2407.18449/) (2024)
- [HiFuse: Hierarchical Multi-Scale Feature Fusion Network for Medical Image Classification](https://mlsanity.com/paper/2209.10218/) (2022)
- [RWKV-CLIP: A Robust Vision-Language Representation Learner](https://mlsanity.com/paper/2406.06973/) (2024)
- [ScoreNet: Learning Non-Uniform Attention and Augmentation for Transformer-Based Histopathological Image Classification](https://mlsanity.com/paper/2202.07570/) (2022)
- [PointRWKV: Efficient RWKV-Like Model for Hierarchical Point Cloud Learning](https://mlsanity.com/paper/2405.15214/) (2024)
- [Mamba or RWKV: Exploring High-Quality and High-Efficiency Segment Anything Model](https://mlsanity.com/paper/2406.19369/) (2024)

## Abstract (arXiv)

Accurate interpretation of histopathological images demands integration of information across spatial and semantic scales, from nuclear morphology and cellular textures to global tissue organization and disease-specific patterns. Although recent foundation models in pathology have shown strong capabilities in capturing global tissue context, their omission of cell-level feature modeling remains a key limitation for fine-grained tasks such as cancer subtype classification. To address this, we propose a dual-stream architecture that models the interplay between macroscale tissue features and aggregated cellular representations. To efficiently aggregate information from large cell sets, we propose a receptance-weighted key-value aggregation model, a recurrent transformer that captures inter-cell dependencies with linear complexity. Furthermore, we introduce a bidirectional tissue-cell interaction module to enable mutual attention between localized cellular cues and their surrounding tissue environment. Experiments on four histopathological subtype classification benchmarks show that the proposed method outperforms existing models, demonstrating the critical role of cell-level aggregation and tissue-cell interaction in fine-grained computational pathology.