# Out-of-Distribution Detection for Safety Assurance of AI and Autonomous Systems

arXiv: https://arxiv.org/abs/2510.21254 · HTML: https://mlsanity.com/paper/2510.21254/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 93 of its 161 references that are in the map.
- First posted on arXiv 24 Oct 2025.

## Builds on (most cited first, 30 of 93)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [Dropout as a Bayesian Approximation: Representing Model Uncertainty in Deep Learning](https://mlsanity.com/paper/1506.02142/) (2015)
- [Auto-Encoding Variational Bayes](https://mlsanity.com/paper/1312.6114/) (2013)
- [Simple and Scalable Predictive Uncertainty Estimation using Deep Ensembles](https://mlsanity.com/paper/1612.01474/) (2016)
- [RT-2: Vision-Language-Action Models Transfer Web Knowledge to Robotic Control](https://mlsanity.com/paper/2307.15818/) (2023)
- [A Baseline for Detecting Misclassified and Out-of-Distribution Examples in Neural Networks](https://mlsanity.com/paper/1610.02136/) (2016)
- [A Simple Unified Framework for Detecting Out-of-Distribution Samples and Adversarial Attacks](https://mlsanity.com/paper/1807.03888/) (2018)
- [Enhancing The Reliability of Out-of-distribution Image Detection in Neural Networks](https://mlsanity.com/paper/1706.02690/) (2017)
- [Energy-based Out-of-distribution Detection](https://mlsanity.com/paper/2010.03759/) (2020)
- [Generalized Out-of-Distribution Detection: A Survey](https://mlsanity.com/paper/2110.11334/) (2021)
- [DivideMix: Learning with Noisy Labels as Semi-supervised Learning](https://mlsanity.com/paper/2002.07394/) (2020)
- [Out-of-Distribution Detection with Deep Nearest Neighbors](https://mlsanity.com/paper/2204.06507/) (2022)
- [Towards Open Set Deep Networks](https://mlsanity.com/paper/1511.06233/) (2015)
- [Using Self-Supervised Learning Can Improve Model Robustness and Uncertainty](https://mlsanity.com/paper/1906.12340/) (2019)
- [ReAct: Out-of-distribution Detection With Rectified Activations](https://mlsanity.com/paper/2111.12797/) (2021)
- [Scaling Out-of-Distribution Detection for Real-World Settings](https://mlsanity.com/paper/1911.11132/) (2019)
- [Likelihood Ratios for Out-of-Distribution Detection](https://mlsanity.com/paper/1906.02845/) (2019)
- [CSI: Novelty Detection via Contrastive Learning on Distributionally Shifted Instances](https://mlsanity.com/paper/2007.08176/) (2020)
- [GANomaly: Semi-Supervised Anomaly Detection via Adversarial Training](https://mlsanity.com/paper/1805.06725/) (2018)
- [Generalized ODIN: Detecting Out-of-distribution Image without Learning from Out-of-distribution Data](https://mlsanity.com/paper/2002.11297/) (2020)
- [Your Classifier is Secretly an Energy Based Model and You Should Treat it Like One](https://mlsanity.com/paper/1912.03263/) (2019)
- [Recent Advances in Open Set Recognition: A Survey](https://mlsanity.com/paper/1811.08581/) (2018)
- [Deep Semi-Supervised Anomaly Detection](https://mlsanity.com/paper/1906.02694/) (2019)
- [Exploring the Limits of Out-of-Distribution Detection](https://mlsanity.com/paper/2106.03004/) (2021)
- [Deep Anomaly Detection Using Geometric Transformations](https://mlsanity.com/paper/1805.10917/) (2018)
- [OpenOOD: Benchmarking Generalized Out-of-Distribution Detection](https://mlsanity.com/paper/2210.07242/) (2022)
- [Learning Confidence for Out-of-Distribution Detection in Neural Networks](https://mlsanity.com/paper/1802.04865/) (2018)
- [A Multimodal Anomaly Detector for Robot-Assisted Feeding Using an LSTM-based Variational Autoencoder](https://mlsanity.com/paper/1711.00614/) (2017)

## Built on by (most cited first, 2 of 2)

- [Generative Control as Optimization: Time Unconditional Flow Matching for Adaptive and Robust Robotic Control](https://mlsanity.com/paper/2603.17834/) (2026)
- [AI Assurance in UK Defence: Challenges in Operationalising JSP 936](https://mlsanity.com/paper/2606.09414/) (2026)

## Abstract (arXiv)

The operational capabilities and application domains of AI-enabled autonomous systems have expanded significantly in recent years due to advances in robotics and machine learning (ML). Demonstrating the safety of autonomous systems rigorously is critical for their responsible adoption but it is challenging as it requires robust methodologies that can handle novel and uncertain situations throughout the system lifecycle, including detecting out-of-distribution (OoD) data. Thus, OOD detection is receiving increased attention from the research, development and safety engineering communities. This comprehensive review analyses OOD detection techniques within the context of safety assurance for autonomous systems, in particular in safety-critical domains. We begin by defining the relevant concepts, investigating what causes OOD and exploring the factors which make the safety assurance of autonomous systems and OOD detection challenging. Our review identifies a range of techniques which can be used throughout the ML development lifecycle and we suggest areas within the lifecycle in which they may be used to support safety assurance arguments. We discuss a number of caveats that system and safety engineers must be aware of when integrating OOD detection into system lifecycles. We conclude by outlining the challenges and future work necessary for the safe development and operation of autonomous systems across a range of domains and applications.