# NeuroGenPoisoning: Neuron-Guided Attacks on Retrieval-Augmented Generation of LLM via Genetic Optimization of External Knowledge

arXiv: https://arxiv.org/abs/2510.21144 · HTML: https://mlsanity.com/paper/2510.21144/

## Key facts

- Cited by 7 papers in the map (data through 14 Oct 2026).
- Placed in Privacy and security of RAG, one of 15 directions in Retrieval-augmented generation.
- Builds on 46 of its 53 references that are in the map.
- First posted on arXiv 24 Oct 2025.

## Placed in

- Retrieval-augmented generation / [Privacy and security of RAG](https://mlsanity.com/rag/privacy-and-security-of-rag/)

## Builds on (most cited first, 30 of 46)

- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [Axiomatic Attribution for Deep Networks](https://mlsanity.com/paper/1703.01365/) (2017)
- [Universal and Transferable Adversarial Attacks on Aligned Language Models](https://mlsanity.com/paper/2307.15043/) (2023)
- [TriviaQA: A Large Scale Distantly Supervised Challenge Dataset for Reading Comprehension](https://mlsanity.com/paper/1705.03551/) (2017)
- [Retrieval-Augmented Generation for Large Language Models: A Survey](https://mlsanity.com/paper/2312.10997/) (2023)
- [REALM: Retrieval-Augmented Language Model Pre-Training](https://mlsanity.com/paper/2002.08909/) (2020)
- [Self-RAG: Learning to Retrieve, Generate, and Critique through Self-Reflection](https://mlsanity.com/paper/2310.11511/) (2023)
- [Know What You Don't Know: Unanswerable Questions for SQuAD](https://mlsanity.com/paper/1806.03822/) (2018)
- [Not what you've signed up for: Compromising Real-World LLM-Integrated Applications with Indirect Prompt Injection](https://mlsanity.com/paper/2302.12173/) (2023)
- [Improving language models by retrieving from trillions of tokens](https://mlsanity.com/paper/2112.04426/) (2021)
- [Ignore Previous Prompt: Attack Techniques For Language Models](https://mlsanity.com/paper/2211.09527/) (2022)
- [AutoDAN: Generating Stealthy Jailbreak Prompts on Aligned Large Language Models](https://mlsanity.com/paper/2310.04451/) (2023)
- [Reading Wikipedia to Answer Open-Domain Questions](https://mlsanity.com/paper/1704.00051/) (2017)
- [Universal Adversarial Triggers for Attacking and Analyzing NLP](https://mlsanity.com/paper/1908.07125/) (2019)
- [Tree of Attacks: Jailbreaking Black-Box LLMs Automatically](https://mlsanity.com/paper/2312.02119/) (2023)
- [A Survey on RAG Meeting LLMs: Towards Retrieval-Augmented Large Language Models](https://mlsanity.com/paper/2405.06211/) (2024)
- [AgentPoison: Red-teaming LLM Agents via Poisoning Memory or Knowledge Bases](https://mlsanity.com/paper/2407.12784/) (2024)
- [Entity-Based Knowledge Conflicts in Question Answering](https://mlsanity.com/paper/2109.05052/) (2021)
- [Adaptive Chameleon or Stubborn Sloth: Revealing the Behavior of Large Language Models in Knowledge Conflicts](https://mlsanity.com/paper/2305.13300/) (2023)
- [Knowledge Conflicts for LLMs: A Survey](https://mlsanity.com/paper/2403.08319/) (2024)
- [PoisonedRAG: Knowledge Corruption Attacks to Retrieval-Augmented Generation of Large Language Models](https://mlsanity.com/paper/2402.07867/) (2024)
- [RankRAG: Unifying Context Ranking with Retrieval-Augmented Generation in LLMs](https://mlsanity.com/paper/2407.02485/) (2024)
- [Poisoning Retrieval Corpora by Injecting Adversarial Passages](https://mlsanity.com/paper/2310.19156/) (2023)
- [Robust Prompt Optimization for Defending Language Models Against Jailbreaking Attacks](https://mlsanity.com/paper/2401.17263/) (2024)
- [On the Risk of Misinformation Pollution with Large Language Models](https://mlsanity.com/paper/2305.13661/) (2023)
- [Automatic and Universal Prompt Injection Attacks against Large Language Models](https://mlsanity.com/paper/2403.04957/) (2024)
- [ClashEval: Quantifying the tug-of-war between an LLM's internal prior and external evidence](https://mlsanity.com/paper/2404.10198/) (2024)
- [Machine Against the RAG: Jamming Retrieval-Augmented Generation with Blocker Documents](https://mlsanity.com/paper/2406.05870/) (2024)
- [Enhancing Noise Robustness of Retrieval-Augmented Language Models with Adaptive Adversarial Training](https://mlsanity.com/paper/2405.20978/) (2024)

## Built on by (most cited first, 7 of 7)

- [Visual Inception: Compromising Long-term Planning in Agentic Recommenders via Multimodal Memory Poisoning](https://mlsanity.com/paper/2604.16966/) (2026)
- [Trust Me, Import This: Dependency Steering Attacks via Malicious Agent Skills](https://mlsanity.com/paper/2605.09594/) (2026)
- [Addressing Corpus Knowledge Poisoning Attacks on RAG Using Sparse Attention](https://mlsanity.com/paper/2602.04711/) (2026)
- [Needle-in-RAG: Prompt-Conditioned Character-Level Traceback of Poisoned Spans in Retrieved Evidence](https://mlsanity.com/paper/2605.01782/) (2026)
- [When Context Bites: Detecting RAG Poisoning via Document-Level Attention Collapse](https://mlsanity.com/paper/2608.06947/) (2026)
- [RAGSieve: Self-Referenced Local Contrast for Knowledge-Poison Detection in Retrieval-Augmented Generation](https://mlsanity.com/paper/2608.13010/) (2026)
- [InceptionRAG: Stealthy Poisoning Attack Against Retrieval-Augmented Generation](https://mlsanity.com/paper/2609.16818/) (2026)

## Abstract (arXiv)

Retrieval-Augmented Generation (RAG) empowers Large Language Models (LLMs) to dynamically integrate external knowledge during inference, improving their factual accuracy and adaptability. However, adversaries can inject poisoned external knowledge to override the model's internal memory. While existing attacks iteratively manipulate retrieval content or prompt structure of RAG, they largely ignore the model's internal representation dynamics and neuron-level sensitivities. The underlying mechanism of RAG poisoning has not been fully studied and the effect of knowledge conflict with strong parametric knowledge in RAG is not considered. In this work, we propose NeuroGenPoisoning, a novel attack framework that generates adversarial external knowledge in RAG guided by LLM internal neuron attribution and genetic optimization. Our method first identifies a set of Poison-Responsive Neurons whose activation strongly correlates with contextual poisoning knowledge. We then employ a genetic algorithm to evolve adversarial passages that maximally activate these neurons. Crucially, our framework enables massive-scale generation of effective poisoned RAG knowledge by identifying and reusing promising but initially unsuccessful external knowledge variants via observed attribution signals. At the same time, Poison-Responsive Neurons guided poisoning can effectively resolves knowledge conflict. Experimental results across models and datasets demonstrate consistently achieving high Population Overwrite Success Rate (POSR) of over 90% while preserving fluency. Empirical evidence shows that our method effectively resolves knowledge conflict.