# Curvilinear Structure-preserving Unpaired Cross-domain Medical Image Translation

arXiv: https://arxiv.org/abs/2510.19679 · HTML: https://mlsanity.com/paper/2510.19679/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 33 of its 60 references that are in the map.
- First posted on arXiv 22 Oct 2025.

## Builds on (most cited first, 30 of 33)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [Mask R-CNN](https://mlsanity.com/paper/1703.06870/) (2017)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [CyCADA: Cycle-Consistent Adversarial Domain Adaptation](https://mlsanity.com/paper/1711.03213/) (2017)
- [Multimodal Unsupervised Image-to-Image Translation](https://mlsanity.com/paper/1804.04732/) (2018)
- [Contrastive Learning for Unpaired Image-to-Image Translation](https://mlsanity.com/paper/2007.15651/) (2020)
- [clDice -- A Novel Topology-Preserving Loss Function for Tubular Structure Segmentation](https://mlsanity.com/paper/2003.07311/) (2020)
- [Diffusion Models for Medical Image Analysis: A Comprehensive Survey](https://mlsanity.com/paper/2211.07804/) (2022)
- [Segment Anything in Medical Images](https://mlsanity.com/paper/2304.12306/) (2023)
- [Dual Diffusion Implicit Bridges for Image-to-Image Translation](https://mlsanity.com/paper/2203.08382/) (2022)
- [Unsupervised Medical Image Translation with Adversarial Diffusion Models](https://mlsanity.com/paper/2207.08208/) (2022)
- [UNIT-DDPM: UNpaired Image Translation with Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2104.05358/) (2021)
- [SAM-Med2D](https://mlsanity.com/paper/2308.16184/) (2023)
- [On the relation between optimal transport and Schr"odinger bridges: A stochastic control viewpoint](https://mlsanity.com/paper/1412.4430/) (2014)
- [Unpaired Image-to-Image Translation via Neural Schr"odinger Bridge](https://mlsanity.com/paper/2305.15086/) (2023)
- [ROSE: A Retinal OCT-Angiography Vessel Segmentation Dataset and New Model](https://mlsanity.com/paper/2007.05201/) (2020)
- [OCTA-500: A Retinal Dataset for Optical Coherence Tomography Angiography Study](https://mlsanity.com/paper/2012.07261/) (2020)
- [Domain Bridge for Unpaired Image-to-Image Translation and Unsupervised Domain Adaptation](https://mlsanity.com/paper/1910.10563/) (2019)
- [Cross-conditioned Diffusion Model for Medical Image to Image Translation](https://mlsanity.com/paper/2409.08500/) (2024)
- [Structure-Preserving Synthesis: MaskGAN for Unpaired MR-CT Translation](https://mlsanity.com/paper/2307.16143/) (2023)
- [AADG: Automatic Augmentation for Domain Generalization on Retinal Image Segmentation](https://mlsanity.com/paper/2207.13249/) (2022)
- [Uncertainty-Guided Progressive GANs for Medical Image Translation](https://mlsanity.com/paper/2106.15542/) (2021)
- [Reducing Domain Gap in Frequency and Spatial domain for Cross-modality Domain Adaptation on Medical Image Segmentation](https://mlsanity.com/paper/2211.15235/) (2022)
- [SemiCurv: Semi-Supervised Curvilinear Structure Segmentation](https://mlsanity.com/paper/2205.08706/) (2022)

## Built on by (most cited first, 1 of 1)

- [In Defense of OCTA: The Reconstruction-Utility Gap in OCT-to-OCTA Synthesis](https://mlsanity.com/paper/2608.15626/) (2026)

## Abstract (arXiv)

Unpaired image-to-image translation has emerged as a crucial technique in medical imaging, enabling cross-modality synthesis, domain adaptation, and data augmentation without costly paired datasets. Yet, existing approaches often distort fine curvilinear structures, such as microvasculature, undermining both diagnostic reliability and quantitative analysis. This limitation is consequential in ophthalmic and vascular imaging, where subtle morphological changes carry significant clinical meaning. We propose Curvilinear Structure-preserving Translation (CST), a general framework that explicitly preserves fine curvilinear structures during unpaired translation by integrating structure consistency into the training. Specifically, CST augments baseline models with a curvilinear extraction module for topological supervision. It can be seamlessly incorporated into existing methods. We integrate it into CycleGAN and UNSB as two representative backbones. Comprehensive evaluation across three imaging modalities: optical coherence tomography angiography, color fundus and X-ray coronary angiography demonstrates that CST improves translation fidelity and achieves state-of-the-art performance. By reinforcing geometric integrity in learned mappings, CST establishes a principled pathway toward curvilinear structure-aware cross-domain translation in medical imaging.