# Enhancing Cross-Patient Generalization in AI-Based Parkinson s Disease Detection

arXiv: https://arxiv.org/abs/2510.17703 · HTML: https://mlsanity.com/paper/2510.17703/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 10 of its 33 references that are in the map.
- First posted on arXiv 20 Oct 2025.

## Builds on (most cited first, 10 of 10)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [MobileNetV2: Inverted Residuals and Linear Bottlenecks](https://mlsanity.com/paper/1801.04381/) (2018)
- [Identity Mappings in Deep Residual Networks](https://mlsanity.com/paper/1603.05027/) (2016)
- [Pyramid Vision Transformer: A Versatile Backbone for Dense Prediction without Convolutions](https://mlsanity.com/paper/2102.12122/) (2021)
- [Learning Transferable Architectures for Scalable Image Recognition](https://mlsanity.com/paper/1707.07012/) (2017)
- [Analysis and Evaluation of Handwriting in Patients with Parkinson's Disease Using kinematic, Geometrical, and Non-linear Features](https://mlsanity.com/paper/2002.05411/) (2020)
- [Dynamically enhanced static handwriting representation for Parkinson's disease detection](https://mlsanity.com/paper/2405.13438/) (2024)

## Abstract (arXiv)

Parkinson's disease (PD) is a neurodegenerative disease affecting about 1% of people over the age of 60, causing motor impairments that impede hand coordination activities such as writing and drawing. Many approaches have tried to support early detection of Parkinson's disease based on hand-drawn images; however, we identified two major limitations in the related works: (1) the lack of sufficient datasets, (2) the robustness when dealing with unseen patient data. In this paper, we propose a new approach to detect Parkinson's disease that consists of two stages: The first stage classifies based on their drawing type(circle, meander, spiral), and the second stage extracts the required features from the images and detects Parkinson's disease. We overcame the previous two limitations by applying a chunking strategy where we divide each image into 2x2 chunks. Each chunk is processed separately when extracting features and recognizing Parkinson's disease indicators. To make the final classification, an ensemble method is used to merge the decisions made from each chunk. Our evaluation shows that our proposed approach outperforms the top performing state-of-the-art approaches, in particular on unseen patients. On the NewHandPD dataset our approach, it achieved 97.08% accuracy for seen patients and 94.91% for unseen patients, our proposed approach maintained a gap of only 2.17 percentage points, compared to the 4.76-point drop observed in prior work.