# Class-N-Diff: Classification-Induced Diffusion Model Can Make Fair Skin Cancer Diagnosis

arXiv: https://arxiv.org/abs/2510.16887 · HTML: https://mlsanity.com/paper/2510.16887/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 20 of its 38 references that are in the map.
- First posted on arXiv 19 Oct 2025.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 20 of 20)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Scalable Diffusion Models with Transformers](https://mlsanity.com/paper/2212.09748/) (2022)
- [Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1710.05006/) (2017)
- [BCN20000: Dermoscopic Lesions in the Wild](https://mlsanity.com/paper/1908.02288/) (2019)
- [Evaluating Deep Neural Networks Trained on Clinical Images in Dermatology with the Fitzpatrick 17k Dataset](https://mlsanity.com/paper/2104.09957/) (2021)
- [A Patient-Centric Dataset of Images and Metadata for Identifying Melanomas Using Clinical Context](https://mlsanity.com/paper/2008.07360/) (2020)
- [Disparities in Dermatology AI: Assessments Using Diverse Clinical Images](https://mlsanity.com/paper/2111.08006/) (2021)
- [Generative models improve fairness of medical classifiers under distribution shifts](https://mlsanity.com/paper/2304.09218/) (2023)
- [FairPrune: Achieving Fairness Through Pruning for Dermatological Disease Diagnosis](https://mlsanity.com/paper/2203.02110/) (2022)
- [Detecting Melanoma Fairly: Skin Tone Detection and Debiasing for Skin Lesion Classification](https://mlsanity.com/paper/2202.02832/) (2022)
- [FairAdaBN: Mitigating unfairness with adaptive batch normalization and its application to dermatological disease classification](https://mlsanity.com/paper/2303.08325/) (2023)
- [Toward Fairness Through Fair Multi-Exit Framework for Dermatological Disease Diagnosis](https://mlsanity.com/paper/2306.14518/) (2023)
- [The (de)biasing effect of GAN-based augmentation methods on skin lesion images](https://mlsanity.com/paper/2206.15182/) (2022)
- [Iterative Online Image Synthesis via Diffusion Model for Imbalanced Classification](https://mlsanity.com/paper/2403.08407/) (2024)
- [FairSkin: Fair Diffusion for Skin Disease Image Generation](https://mlsanity.com/paper/2410.22551/) (2024)
- [DermDiff: Generative Diffusion Model for Mitigating Racial Biases in Dermatology Diagnosis](https://mlsanity.com/paper/2503.17536/) (2025)
- [Multi-Adversarial Variational Autoencoder Networks](https://mlsanity.com/paper/1906.06430/) (2019)
- [Prompting Medical Vision-Language Models to Mitigate Diagnosis Bias by Generating Realistic Dermoscopic Images](https://mlsanity.com/paper/2504.01838/) (2025)

## Abstract (arXiv)

Generative models, especially Diffusion Models, have demonstrated remarkable capability in generating high-quality synthetic data, including medical images. However, traditional class-conditioned generative models often struggle to generate images that accurately represent specific medical categories, limiting their usefulness for applications such as skin cancer diagnosis. To address this problem, we propose a classification-induced diffusion model, namely, Class-N-Diff, to simultaneously generate and classify dermoscopic images. Our Class-N-Diff model integrates a classifier within a diffusion model to guide image generation based on its class conditions. Thus, the model has better control over class-conditioned image synthesis, resulting in more realistic and diverse images. Additionally, the classifier demonstrates improved performance, highlighting its effectiveness for downstream diagnostic tasks. This unique integration in our Class-N-Diff makes it a robust tool for enhancing the quality and utility of diffusion model-based synthetic dermoscopic image generation. Our code is available at https://github.com/Munia03/Class-N-Diff.