# SDPA++: A General Framework for Self-Supervised Denoising with Patch Aggregation

arXiv: https://arxiv.org/abs/2510.16702 · HTML: https://mlsanity.com/paper/2510.16702/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 21 references that are in the map.
- First posted on arXiv 19 Oct 2025.

## Builds on (most cited first, 13 of 13)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Restormer: Efficient Transformer for High-Resolution Image Restoration](https://mlsanity.com/paper/2111.09881/) (2021)
- [Simple Baselines for Image Restoration](https://mlsanity.com/paper/2204.04676/) (2022)
- [Noise2Noise: Learning Image Restoration without Clean Data](https://mlsanity.com/paper/1803.04189/) (2018)
- [Noise2Void - Learning Denoising from Single Noisy Images](https://mlsanity.com/paper/1811.10980/) (2018)
- [Noise2Self: Blind Denoising by Self-Supervision](https://mlsanity.com/paper/1901.11365/) (2019)
- [Neighbor2Neighbor: Self-Supervised Denoising from Single Noisy Images](https://mlsanity.com/paper/2101.02824/) (2021)
- [High-Quality Self-Supervised Deep Image Denoising](https://mlsanity.com/paper/1901.10277/) (2019)
- [AP-BSN: Self-Supervised Denoising for Real-World Images via Asymmetric PD and Blind-Spot Network](https://mlsanity.com/paper/2203.11799/) (2022)
- [Blind2Unblind: Self-Supervised Image Denoising with Visible Blind Spots](https://mlsanity.com/paper/2203.06967/) (2022)
- [CascadedGaze: Efficiency in Global Context Extraction for Image Restoration](https://mlsanity.com/paper/2401.15235/) (2024)
- [Generalized Recorrupted-to-Recorrupted: Self-Supervised Learning Beyond Gaussian Noise](https://mlsanity.com/paper/2412.04648/) (2024)

## Abstract (arXiv)

Optical Coherence Tomography (OCT) is a widely used non-invasive imaging technique that provides detailed three-dimensional views of the retina, which are essential for the early and accurate diagnosis of ocular diseases. Consequently, OCT image analysis and processing have emerged as key research areas in biomedical imaging. However, acquiring paired datasets of clean and real-world noisy OCT images for supervised denoising models remains a formidable challenge due to intrinsic speckle noise and practical constraints in clinical imaging environments. To address these issues, we propose SDPA++: A General Framework for Self-Supervised Denoising with Patch Aggregation. Our novel approach leverages only noisy OCT images by first generating pseudo-ground-truth images through self-fusion and self-supervised denoising. These refined images then serve as targets to train an ensemble of denoising models using a patch-based strategy that effectively enhances image clarity. Performance improvements are validated via metrics such as Contrast-to-Noise Ratio (CNR), Mean Square Ratio (MSR), Texture Preservation (TP), and Edge Preservation (EP) on the real-world dataset from the IEEE SPS Video and Image Processing Cup. Notably, the VIP Cup dataset contains only real-world noisy OCT images without clean references, highlighting our method's potential for improving image quality and diagnostic outcomes in clinical practice.