# Demo: Guide-RAG: Evidence-Driven Corpus Curation for Retrieval-Augmented Generation in Long COVID

arXiv: https://arxiv.org/abs/2510.15782 · HTML: https://mlsanity.com/paper/2510.15782/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Placed in Medical and biomedical RAG, one of 15 directions in Retrieval-augmented generation.
- Builds on 11 of its 40 references that are in the map.
- First posted on arXiv 17 Oct 2025.

## Placed in

- Retrieval-augmented generation / [Medical and biomedical RAG](https://mlsanity.com/rag/medical-and-biomedical-rag/)

## Builds on (most cited first, 11 of 11)

- [Judging LLM-as-a-Judge with MT-Bench and Chatbot Arena](https://mlsanity.com/paper/2306.05685/) (2023)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [From Local to Global: A Graph RAG Approach to Query-Focused Summarization](https://mlsanity.com/paper/2404.16130/) (2024)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answering](https://mlsanity.com/paper/2203.14371/) (2022)
- [Ragas: Automated Evaluation of Retrieval Augmented Generation](https://mlsanity.com/paper/2309.15217/) (2023)
- [Benchmarking Retrieval-Augmented Generation for Medicine](https://mlsanity.com/paper/2402.13178/) (2024)
- [Can Generalist Foundation Models Outcompete Special-Purpose Tuning? Case Study in Medicine](https://mlsanity.com/paper/2311.16452/) (2023)
- [Medical Graph RAG: Towards Safe Medical Large Language Model via Graph Retrieval-Augmented Generation](https://mlsanity.com/paper/2408.04187/) (2024)
- [MedHELM: Holistic Evaluation of Large Language Models for Medical Tasks](https://mlsanity.com/paper/2505.23802/) (2025)

## Built on by (most cited first, 3 of 3)

- [Learning from AVA: Early Lessons from a Curated and Trustworthy Generative AI for Policy and Development Research](https://mlsanity.com/paper/2604.17843/) (2026)
- [Grounded in Consensus, In Step With Emerging Science: A Consensus-Anchored Multi-Corpus Clinical Chatbot for Long COVID](https://mlsanity.com/paper/2607.25038/) (2026)
- [A corpus-specific clinical RAG system matches or outperforms newer frontier LLMs on HealthBench](https://mlsanity.com/paper/2608.12138/) (2026)

## Abstract (arXiv)

As AI chatbots gain adoption in clinical medicine, developing effective frameworks for complex, emerging diseases presents significant challenges. We developed and evaluated six Retrieval-Augmented Generation (RAG) corpus configurations for Long COVID (LC) clinical question answering, ranging from expert-curated sources to large-scale literature databases. Our evaluation employed an LLM-as-a-judge framework across faithfulness, relevance, and comprehensiveness metrics using LongCOVID-CQ, a novel dataset of expert-generated clinical questions. Our RAG corpus configuration combining clinical guidelines with high-quality systematic reviews consistently outperformed both narrow single-guideline approaches and large-scale literature databases. Our findings suggest that for emerging diseases, retrieval grounded in curated secondary reviews provides an optimal balance between narrow consensus documents and unfiltered primary literature, supporting clinical decision-making while avoiding information overload and oversimplified guidance. We propose Guide-RAG, a chatbot system and accompanying evaluation framework that integrates both curated expert knowledge and comprehensive literature databases to effectively answer LC clinical questions.