# Robust High-Resolution Multi-Organ Diffusion MRI Using Synthetic-Data-Tuned Prompt Learning

arXiv: https://arxiv.org/abs/2510.15400 · HTML: https://mlsanity.com/paper/2510.15400/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 8 of its 25 references that are in the map.
- First posted on arXiv 17 Oct 2025.

## Builds on (most cited first, 8 of 8)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [One-dimensional Deep Low-rank and Sparse Network for Accelerated MRI](https://mlsanity.com/paper/2112.04721/) (2021)
- [Physics-driven Synthetic Data Learning for Biomedical Magnetic Resonance](https://mlsanity.com/paper/2203.11178/) (2022)
- [One for Multiple: Physics-informed Synthetic Data Boosts Generalizable Deep Learning for Fast MRI Reconstruction](https://mlsanity.com/paper/2307.13220/) (2023)
- [MoDL-MUSSELS: Model-Based Deep Learning for Multi-Shot Sensitivity Encoded Diffusion MRI](https://mlsanity.com/paper/1812.08115/) (2018)
- [A Paired Phase and Magnitude Reconstruction for Advanced Diffusion-Weighted Imaging](https://mlsanity.com/paper/2203.14559/) (2022)
- [CloudBrain-ReconAI: An Online Platform for MRI Reconstruction and Image Quality Evaluation](https://mlsanity.com/paper/2212.01878/) (2022)
- [Robust Autocalibrated Structured Low-Rank EPI Ghost Correction](https://mlsanity.com/paper/1907.13261/) (2019)

## Abstract (arXiv)

Clinical adoption of multi-shot diffusion-weighted magnetic resonance imaging (multi-shot DWI) for body-wide tumor diagnostics is limited by severe motion-induced phase artifacts from respiration, peristalsis, and so on, compounded by multi-organ, multi-slice, multi-direction and multi-b-value complexities. Here, we introduce a reconstruction framework, LoSP-Prompt, that overcomes these challenges through physics-informed modeling and synthetic-data-driven prompt learning. We model inter-shot phase variations as a high-order Locally Smooth Phase (LoSP), integrated into a low-rank Hankel matrix reconstruction. Crucially, the algorithm's rank parameter is automatically set via prompt learning trained exclusively on synthetic abdominal DWI data emulating physiological motion. Validated across 10,000+ clinical images (43 subjects, 4 scanner models, 5 centers), LoSP-Prompt: (1) Achieved twice the spatial resolution of clinical single-shot DWI, enhancing liver lesion conspicuity; (2) Generalized to seven diverse anatomical regions (liver, kidney, sacroiliac, pelvis, knee, spinal cord, brain) with a single model; (3) Outperformed state-of-the-art methods in image quality, artifact suppression, and noise reduction (11 radiologists' evaluations on a 5-point scale, p<0.05), achieving 4-5 points (excellent) on kidney DWI, 4 points (good to excellent) on liver, sacroiliac and spinal cord DWI, and 3-4 points (good) on knee and tumor brain. The approach eliminates navigator signals and realistic data supervision, providing an interpretable, robust solution for high-resolution multi-organ multi-shot DWI. Its scanner-agnostic performance signifies transformative potential for precision oncology.