# AI-Powered Early Diagnosis of Mental Health Disorders from Real-World Clinical Conversations

arXiv: https://arxiv.org/abs/2510.14937 · HTML: https://mlsanity.com/paper/2510.14937/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 7 of its 56 references that are in the map.
- First posted on arXiv 16 Oct 2025.

## Builds on (most cited first, 7 of 7)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [RoBERTa: A Robustly Optimized BERT Pretraining Approach](https://mlsanity.com/paper/1907.11692/) (2019)
- [Sentence-BERT: Sentence Embeddings using Siamese BERT-Networks](https://mlsanity.com/paper/1908.10084/) (2019)
- [Large Language Models Are Zero-Shot Text Classifiers](https://mlsanity.com/paper/2312.01044/) (2023)
- [Zero- and Few-Shot Prompting with LLMs: A Comparative Study with Fine-tuned Models for Bangla Sentiment Analysis](https://mlsanity.com/paper/2308.10783/) (2023)
- [MDD-LLM: Towards Accuracy Large Language Models for Major Depressive Disorder Diagnosis](https://mlsanity.com/paper/2505.00032/) (2025)
- [Emotions, Context, and Substance Use in Adolescents: A Large Language Model Analysis of Reddit Posts](https://mlsanity.com/paper/2501.14037/) (2025)

## Abstract (arXiv)

Mental health disorders remain among the leading cause of disability worldwide, yet conditions such as depression, anxiety, and Post-Traumatic Stress Disorder (PTSD) are frequently underdiagnosed or misdiagnosed due to subjective assessments, limited clinical resources, and stigma and low awareness. In primary care settings, studies show that providers misidentify depression or anxiety in over 60% of cases, highlighting the urgent need for scalable, accessible, and context-aware diagnostic tools that can support early detection and intervention. In this study, we evaluate the effectiveness of machine learning models for mental health screening using a unique dataset of 553 real-world, semistructured interviews, each paried with ground-truth diagnoses for major depressive episodes (MDE), anxiety disorders, and PTSD. We benchmark multiple model classes, including zero-shot prompting with GPT-4.1 Mini and MetaLLaMA, as well as fine-tuned RoBERTa models using LowRank Adaptation (LoRA). Our models achieve over 80% accuracy across diagnostic categories, with especially strongperformance on PTSD (up to 89% accuracy and 98% recall). We also find that using shorter context, focused context segments improves recall, suggesting that focused narrative cues enhance detection sensitivity. LoRA fine-tuning proves both efficient and effective, with lower-rank configurations (e.g., rank 8 and 16) maintaining competitive performance across evaluation metrics. Our results demonstrate that LLM-based models can offer substantial improvements over traditional self-report screening tools, providing a path toward low-barrier, AI-powerd early diagnosis. This work lays the groundwork for integrating machine learning into real-world clinical workflows, particularly in low-resource or high-stigma environments where access to timely mental health care is most limited.