# Scaling Artificial Intelligence for Multi-Tumor Early Detection with More Reports, Fewer Masks

arXiv: https://arxiv.org/abs/2510.14803 · HTML: https://mlsanity.com/paper/2510.14803/

## Key facts

- Cited by 9 papers in the map (data through 14 Oct 2026).
- Builds on 30 of its 57 references that are in the map.
- First posted on arXiv 16 Oct 2025.

## Builds on (most cited first, 30 of 30)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Unsupervised Representation Learning with Deep Convolutional Generative Adversarial Networks](https://mlsanity.com/paper/1511.06434/) (2015)
- [Shortcut Learning in Deep Neural Networks](https://mlsanity.com/paper/2004.07780/) (2020)
- [CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparison](https://mlsanity.com/paper/1901.07031/) (2019)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)
- [The Medical Segmentation Decathlon](https://mlsanity.com/paper/2106.05735/) (2021)
- [TotalSegmentator: robust segmentation of 104 anatomical structures in CT images](https://mlsanity.com/paper/2208.05868/) (2022)
- [The Liver Tumor Segmentation Benchmark (LiTS)](https://mlsanity.com/paper/1901.04056/) (2019)
- [MedGemma Technical Report](https://mlsanity.com/paper/2507.05201/) (2025)
- [The state of the art in kidney and kidney tumor segmentation in contrast-enhanced CT imaging: Results of the KiTS19 Challenge](https://mlsanity.com/paper/1912.01054/) (2019)
- [PANDA: Adapting Pretrained Features for Anomaly Detection and Segmentation](https://mlsanity.com/paper/2010.05903/) (2020)
- [Merlin: A Computed Tomography Vision-Language Foundation Model and Dataset](https://mlsanity.com/paper/2406.06512/) (2024)
- [CT2Rep: Automated Radiology Report Generation for 3D Medical Imaging](https://mlsanity.com/paper/2403.06801/) (2024)
- [AbdomenAtlas: A Large-Scale, Detailed-Annotated, & Multi-Center Dataset for Efficient Transfer Learning and Open Algorithmic Benchmarking](https://mlsanity.com/paper/2407.16697/) (2024)
- [A Data-scalable Transformer for Medical Image Segmentation: Architecture, Model Efficiency, and Benchmark](https://mlsanity.com/paper/2203.00131/) (2022)
- [RadGPT: Constructing 3D Image-Text Tumor Datasets](https://mlsanity.com/paper/2501.04678/) (2025)
- [Universal and Extensible Language-Vision Models for Organ Segmentation and Tumor Detection from Abdominal Computed Tomography](https://mlsanity.com/paper/2405.18356/) (2024)
- [Touchstone Benchmark: Are We on the Right Way for Evaluating AI Algorithms for Medical Segmentation?](https://mlsanity.com/paper/2411.03670/) (2024)
- [The ULS23 Challenge: a Baseline Model and Benchmark Dataset for 3D Universal Lesion Segmentation in Computed Tomography](https://mlsanity.com/paper/2406.05231/) (2024)
- [Improving deep neural network generalization and robustness to background bias via layer-wise relevance propagation optimization](https://mlsanity.com/paper/2202.00232/) (2022)
- [Advancing Volumetric Medical Image Segmentation via Global-Local Masked Autoencoder](https://mlsanity.com/paper/2306.08913/) (2023)
- [MiM: Mask in Mask Self-Supervised Pre-Training for 3D Medical Image Analysis](https://mlsanity.com/paper/2404.15580/) (2024)
- [PanTS: The Pancreatic Tumor Segmentation Dataset](https://mlsanity.com/paper/2507.01291/) (2025)
- [CancerUniT: Towards a Single Unified Model for Effective Detection, Segmentation, and Diagnosis of Eight Major Cancers Using a Large Collection of CT Scans](https://mlsanity.com/paper/2301.12291/) (2023)
- [Are Vision Language Models Ready for Clinical Diagnosis? A 3D Medical Benchmark for Tumor-centric Visual Question Answering](https://mlsanity.com/paper/2505.18915/) (2025)
- [Boosting Vision Semantic Density with Anatomy Normality Modeling for Medical Vision-language Pre-training](https://mlsanity.com/paper/2508.03742/) (2025)
- [Learning Segmentation from Radiology Reports](https://mlsanity.com/paper/2507.05582/) (2025)
- [Mamba Goes HoME: Hierarchical Soft Mixture-of-Experts for 3D Medical Image Segmentation](https://mlsanity.com/paper/2507.06363/) (2025)

## Built on by (most cited first, 9 of 9)

- [Early and Prediagnostic Detection of Pancreatic Cancer from Computed Tomography](https://mlsanity.com/paper/2601.22134/) (2026)
- [RadThinking: A Dataset for Longitudinal Clinical Reasoning in Radiology](https://mlsanity.com/paper/2605.10761/) (2026)
- [See More, Change Less: Anatomy-Aware Diffusion for Contrast Enhancement](https://mlsanity.com/paper/2512.07251/) (2025)
- [BenchX: Benchmarking AI Models for Cancer Detection and Localization with Demographic and Protocol Biases](https://mlsanity.com/paper/2606.24883/) (2026)
- [Open-Ended CT Volume Segmentation with Weak Supervision from Language](https://mlsanity.com/paper/2607.25860/) (2026)
- [Beyond Masks: The Case for Medical Image Parsing](https://mlsanity.com/paper/2605.11438/) (2026)
- [Report Supervision](https://mlsanity.com/paper/2608.27668/) (2026)
- [RT-Super: Learning Tumor Segmentation from Longitudinal Images and Reports](https://mlsanity.com/paper/2609.35637/) (2026)
- [Merlin Plus: A Large-Scale, Multi-Cancer, Image-Mask-Report Dataset](https://mlsanity.com/paper/2609.36436/) (2026)

## Abstract (arXiv)

Early tumor detection save lives. Each year, more than 300 million computed tomography (CT) scans are performed worldwide, offering a vast opportunity for effective cancer screening. However, detecting small or early-stage tumors on these CT scans remains challenging, even for experts. Artificial intelligence (AI) models can assist by highlighting suspicious regions, but training such models typically requires extensive tumor masks--detailed, voxel-wise outlines of tumors manually drawn by radiologists. Drawing these masks is costly, requiring years of effort and millions of dollars. In contrast, nearly every CT scan in clinical practice is already accompanied by medical reports describing the tumor's size, number, appearance, and sometimes, pathology results--information that is rich, abundant, and often underutilized for AI training. We introduce R-Super, which trains AI to segment tumors that match their descriptions in medical reports. This approach scales AI training with large collections of readily available medical reports, substantially reducing the need for manually drawn tumor masks. When trained on 101,654 reports, AI models achieved performance comparable to those trained on 723 masks. Combining reports and masks further improved sensitivity by +13% and specificity by +8%, surpassing radiologists in detecting five of the seven tumor types. Notably, R-Super enabled segmentation of tumors in the spleen, gallbladder, prostate, bladder, uterus, and esophagus, for which no public masks or AI models previously existed. This study challenges the long-held belief that large-scale, labor-intensive tumor mask creation is indispensable, establishing a scalable and accessible path toward early detection across diverse tumor types. We plan to release our trained models, code, and dataset at https://github.com/MrGiovanni/R-Super