# DRBD-Mamba for Robust and Efficient Brain Tumor Segmentation with Analytical Insights

arXiv: https://arxiv.org/abs/2510.14383 · HTML: https://mlsanity.com/paper/2510.14383/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Placed in Mamba for medical image analysis, one of 10 directions in State-space sequence models (S4, Mamba).
- Builds on 23 of its 55 references that are in the map.
- First posted on arXiv 16 Oct 2025.

## Placed in

- State-space sequence models (S4, Mamba) / [Mamba for medical image analysis](https://mlsanity.com/ssm/mamba-for-medical-image-analysis/)

## Builds on (most cited first, 23 of 23)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [Vision Mamba: Efficient Visual Representation Learning with Bidirectional State Space Model](https://mlsanity.com/paper/2401.09417/) (2024)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Images](https://mlsanity.com/paper/2201.01266/) (2022)
- [The RSNA-ASNR-MICCAI BraTS 2021 Benchmark on Brain Tumor Segmentation and Radiogenomic Classification](https://mlsanity.com/paper/2107.02314/) (2021)
- [Activating More Pixels in Image Super-Resolution Transformer](https://mlsanity.com/paper/2205.04437/) (2022)
- [3D MRI brain tumor segmentation using autoencoder regularization](https://mlsanity.com/paper/1810.11654/) (2018)
- [SegMamba: Long-range Sequential Modeling Mamba For 3D Medical Image Segmentation](https://mlsanity.com/paper/2401.13560/) (2024)
- [TransBTS: Multimodal Brain Tumor Segmentation Using Transformer](https://mlsanity.com/paper/2103.04430/) (2021)
- [MedNeXt: Transformer-driven Scaling of ConvNets for Medical Image Segmentation](https://mlsanity.com/paper/2303.09975/) (2023)
- [3D UX-Net: A Large Kernel Volumetric ConvNet Modernizing Hierarchical Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2209.15076/) (2022)
- [BiTr-Unet: a CNN-Transformer Combined Network for MRI Brain Tumor Segmentation](https://mlsanity.com/paper/2109.12271/) (2021)
- [QuadMamba: Learning Quadtree-based Selective Scan for Visual State Space Model](https://mlsanity.com/paper/2410.06806/) (2024)
- [1M parameters are enough? A lightweight CNN-based model for medical image segmentation](https://mlsanity.com/paper/2306.16103/) (2023)
- [A Survey on Mamba Architecture for Vision Applications](https://mlsanity.com/paper/2502.07161/) (2025)
- [Brain Tumor Segmentation and Survival Prediction using Automatic Hard mining in 3D CNN Architecture](https://mlsanity.com/paper/2101.01546/) (2021)
- [Space-filling Curves for High-performance Data Mining](https://mlsanity.com/paper/2008.01684/) (2020)
- [Volumetric medical image segmentation through dual self-distillation in U-shaped networks](https://mlsanity.com/paper/2306.03271/) (2023)
- [Multimodal MRI brain tumor segmentation using random forests with features learned from fully convolutional neural network](https://mlsanity.com/paper/1704.08134/) (2017)

## Built on by (most cited first, 3 of 3)

- [ReFRM3D: A Radiomics-enhanced Fused Residual Multiparametric 3D Network with Multi-Scale Feature Fusion for Glioma Characterization](https://mlsanity.com/paper/2512.22570/) (2025)
- [MHMamba: Multi-Head Mamba for 3D Brain Tumor Segmentation](https://mlsanity.com/paper/2605.16464/) (2026)
- [D3Seg: Dependency-Aware Diffusion for Brain Tumor Segmentation with Missing Modalities](https://mlsanity.com/paper/2605.22249/) (2026)

## Abstract (arXiv)

Accurate brain tumor segmentation is significant for clinical diagnosis and treatment but remains challenging due to tumor heterogeneity. Mamba-based State Space Models have demonstrated promising performance. However, despite their computational efficiency over other neural architectures, they incur considerable overhead for this task due to their sequential feature computation across multiple spatial axes. Moreover, their robustness across diverse BraTS data partitions remains largely unexplored, leaving a critical gap in reliable evaluation. To address this, we first propose a dual-resolution bi-directional Mamba (DRBD-Mamba), an efficient 3D segmentation model that captures multi-scale long-range dependencies with minimal computational overhead. We leverage a space-filling curve to preserve spatial locality during 3D-to-1D feature mapping, thereby reducing reliance on computationally expensive multi-axial feature scans. To enrich feature representation, we propose a gated fusion module that adaptively integrates forward and reverse contexts, along with a quantization block that improves robustness. We further propose five systematic folds on BraTS2023 for rigorous evaluation of segmentation techniques under diverse conditions and present analysis of common failure scenarios. On the 20% test set used by recent methods, our model achieves Dice improvements of 0.10% for whole tumor, 1.75% for tumor core, and 0.93% for enhancing tumor. Evaluations on the proposed systematic folds demonstrate that our model maintains competitive whole tumor accuracy while achieving clear average Dice gains of 1.16% for tumor core and 1.68% for enhancing tumor over existing state-of-the-art. Furthermore, our model achieves a 15x efficiency improvement while maintaining high segmentation accuracy, highlighting its robustness and computational advantage over existing methods.