# Steerable Conditional Diffusion for Domain Adaptation in PET Image Reconstruction

arXiv: https://arxiv.org/abs/2510.13441 · HTML: https://mlsanity.com/paper/2510.13441/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 4 of its 6 references that are in the map.
- First posted on arXiv 15 Oct 2025.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 4 of 4)

- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Score-Based Generative Models for PET Image Reconstruction](https://mlsanity.com/paper/2308.14190/) (2023)
- [Steerable Conditional Diffusion for Out-of-Distribution Adaptation in Medical Image Reconstruction](https://mlsanity.com/paper/2308.14409/) (2023)
- [Likelihood-Scheduled Score-Based Generative Modeling for Fully 3D PET Image Reconstruction](https://mlsanity.com/paper/2412.04339/) (2024)

## Built on by (most cited first, 1 of 1)

- [PET-Adapter: Test-Time Domain Adaptation for Full and Limited-Angle PET Image Reconstruction](https://mlsanity.com/paper/2605.08030/) (2026)

## Abstract (arXiv)

Diffusion models have recently enabled state-of-the-art reconstruction of positron emission tomography (PET) images while requiring only image training data. However, domain shift remains a key concern for clinical adoption: priors trained on images from one anatomy, acquisition protocol or pathology may produce artefacts on out-of-distribution data. We propose integrating steerable conditional diffusion (SCD) with our previously-introduced likelihood-scheduled diffusion (PET-LiSch) framework to improve the alignment of the diffusion model's prior to the target subject. At reconstruction time, for each diffusion step, we use low-rank adaptation (LoRA) to align the diffusion model prior with the target domain on the fly. Experiments on realistic synthetic 2D brain phantoms demonstrate that our approach suppresses hallucinated artefacts under domain shift, i.e. when our diffusion model is trained on perturbed images and tested on normal anatomy, our approach suppresses the hallucinated structure, outperforming both OSEM and diffusion model baselines qualitatively and quantitatively. These results provide a proof-of-concept that steerable priors can mitigate domain shift in diffusion-based PET reconstruction and motivate future evaluation on real data.