# Synergistic Modality-and-Slice Memory Framework for Cross-Modal 3D Brain Tumor Segmentation

arXiv: https://arxiv.org/abs/2510.10679 · HTML: https://mlsanity.com/paper/2510.10679/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 33 of its 53 references that are in the map.
- First posted on arXiv 12 Oct 2025.

## Builds on (most cited first, 30 of 33)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [SAM 2: Segment Anything in Images and Videos](https://mlsanity.com/paper/2408.00714/) (2024)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [VMamba: Visual State Space Model](https://mlsanity.com/paper/2401.10166/) (2024)
- [U-Mamba: Enhancing Long-range Dependency for Biomedical Image Segmentation](https://mlsanity.com/paper/2401.04722/) (2024)
- [Hiera: A Hierarchical Vision Transformer without the Bells-and-Whistles](https://mlsanity.com/paper/2306.00989/) (2023)
- [SegMamba: Long-range Sequential Modeling Mamba For 3D Medical Image Segmentation](https://mlsanity.com/paper/2401.13560/) (2024)
- [TransBTS: Multimodal Brain Tumor Segmentation Using Transformer](https://mlsanity.com/paper/2103.04430/) (2021)
- [nnU-Net Revisited: A Call for Rigorous Validation in 3D Medical Image Segmentation](https://mlsanity.com/paper/2404.09556/) (2024)
- [nnFormer: Interleaved Transformer for Volumetric Segmentation](https://mlsanity.com/paper/2109.03201/) (2021)
- [Medical SAM 2: Segment medical images as video via Segment Anything Model 2](https://mlsanity.com/paper/2408.00874/) (2024)
- [UNETR++: Delving into Efficient and Accurate 3D Medical Image Segmentation](https://mlsanity.com/paper/2212.04497/) (2022)
- [Vision-RWKV: Efficient and Scalable Visual Perception with RWKV-Like Architectures](https://mlsanity.com/paper/2403.02308/) (2024)
- [MA-SAM: Modality-agnostic SAM Adaptation for 3D Medical Image Segmentation](https://mlsanity.com/paper/2309.08842/) (2023)
- [The 2024 Brain Tumor Segmentation (BraTS) Challenge: Glioma Segmentation on Post-treatment MRI](https://mlsanity.com/paper/2405.18368/) (2024)
- [SAM2-Adapter: Evaluating & Adapting Segment Anything 2 in Downstream Tasks: Camouflage, Shadow, Medical Image Segmentation, and More](https://mlsanity.com/paper/2408.04579/) (2024)
- [Memory Aggregation Networks for Efficient Interactive Video Object Segmentation](https://mlsanity.com/paper/2003.13246/) (2020)
- [DCSAU-Net: A Deeper and More Compact Split-Attention U-Net for Medical Image Segmentation](https://mlsanity.com/paper/2202.00972/) (2022)
- [The Brain Tumor Segmentation (BraTS-METS) Challenge 2023: Brain Metastasis Segmentation on Pre-treatment MRI](https://mlsanity.com/paper/2306.00838/) (2023)
- [NestedFormer: Nested Modality-Aware Transformer for Brain Tumor Segmentation](https://mlsanity.com/paper/2208.14876/) (2022)
- [Analysis of the MICCAI Brain Tumor Segmentation -- Metastases (BraTS-METS) 2025 Lighthouse Challenge: Brain Metastasis Segmentation on Pre- and Post-treatment MRI](https://mlsanity.com/paper/2504.12527/) (2025)
- [ReSurgSAM2: Referring Segment Anything in Surgical Video via Credible Long-term Tracking](https://mlsanity.com/paper/2505.08581/) (2025)
- [Self-Prompt SAM: Medical Image Segmentation via Automatic Prompt SAM Adaptation](https://mlsanity.com/paper/2502.00630/) (2025)
- [CRISP-SAM2: SAM2 with Cross-Modal Interaction and Semantic Prompting for Multi-Organ Segmentation](https://mlsanity.com/paper/2506.23121/) (2025)
- [Rethinking Brain Tumor Segmentation from the Frequency Domain Perspective](https://mlsanity.com/paper/2506.10142/) (2025)
- [SAMed-2: Selective Memory Enhanced Medical Segment Anything Model](https://mlsanity.com/paper/2507.03698/) (2025)
- [Memory-Augmented SAM2 for Training-Free Surgical Video Segmentation](https://mlsanity.com/paper/2507.09577/) (2025)
- [BGF-YOLO: Enhanced YOLOv8 with Multiscale Attentional Feature Fusion for Brain Tumor Detection](https://mlsanity.com/paper/2309.12585/) (2023)
- [3D-TransUNet for Brain Metastases Segmentation in the BraTS2023 Challenge](https://mlsanity.com/paper/2403.15735/) (2024)

## Abstract (arXiv)

The 3D multi-modal brain tumor segmentation is critical to multi-modal healthcare, and it requires accurate identification of distinct internal anatomical subregions. While the recent prompt-based segmentation paradigms enable interactive experiences for clinicians, existing methods ignore cross-modal correlations and rely on labor-intensive category-specific prompts, limiting their applicability in real-world scenarios. To address these issues, we propose the MSM-Seg, a synergistic framework for multi-modal brain tumor segmentation. The MSM-Seg introduces a dual-memory segmentation paradigm that synergistically integrates multi-modal and inter-slice information with an efficient category-agnostic prompt for brain tumor understanding. To this end, we first devise a modality-and-slice memory attention (MSMA) to exploit the complex cross-modal correlations and spatial-slice dependencies among the input scans. czThen, we propose a multi-scale category-agnostic prompt encoder (MCP-Encoder) to provide whole tumor region guidance for decoding. Moreover, we devise a modality-adaptive fusion decoder (MF-Decoder) that leverages the complementary decoding information across different modalities to improve segmentation accuracy. Extensive experiments on different MRI datasets demonstrate that our MSM-Seg framework outperforms state-of-the-art methods in multi-modal metastases and glioma tumor segmentation. The code is available at https://github.com/xq141839/MSM-Seg.