# Are Video Models Emerging as Zero-Shot Learners and Reasoners in Medical Imaging?

arXiv: https://arxiv.org/abs/2510.10254 · HTML: https://mlsanity.com/paper/2510.10254/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 25 of its 39 references that are in the map.
- First posted on arXiv 11 Oct 2025.

## Builds on (most cited first, 25 of 25)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Neural Discrete Representation Learning](https://mlsanity.com/paper/1711.00937/) (2017)
- [Taming Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2012.09841/) (2020)
- [Imagen Video: High Definition Video Generation with Diffusion Models](https://mlsanity.com/paper/2210.02303/) (2022)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [Convolutional LSTM Network: A Machine Learning Approach for Precipitation Nowcasting](https://mlsanity.com/paper/1506.04214/) (2015)
- [VideoGPT: Video Generation using VQ-VAE and Transformers](https://mlsanity.com/paper/2104.10157/) (2021)
- [TotalSegmentator: robust segmentation of 104 anatomical structures in CT images](https://mlsanity.com/paper/2208.05868/) (2022)
- [MedCLIP: Contrastive Learning from Unpaired Medical Images and Text](https://mlsanity.com/paper/2210.10163/) (2022)
- [BiomedCLIP: a multimodal biomedical foundation model pretrained from fifteen million scientific image-text pairs](https://mlsanity.com/paper/2303.00915/) (2023)
- [MedGemma Technical Report](https://mlsanity.com/paper/2507.05201/) (2025)
- [Med-Flamingo: a Multimodal Medical Few-shot Learner](https://mlsanity.com/paper/2307.15189/) (2023)
- [Making the Most of Text Semantics to Improve Biomedical Vision--Language Processing](https://mlsanity.com/paper/2204.09817/) (2022)
- [Video models are zero-shot learners and reasoners](https://mlsanity.com/paper/2509.20328/) (2025)
- [Sequential Modeling Enables Scalable Learning for Large Vision Models](https://mlsanity.com/paper/2312.00785/) (2023)
- [Med-R1: Reinforcement Learning for Generalizable Medical Reasoning in Vision-Language Models](https://mlsanity.com/paper/2503.13939/) (2025)
- [AbdomenAtlas: A Large-Scale, Detailed-Annotated, & Multi-Center Dataset for Efficient Transfer Learning and Open Algorithmic Benchmarking](https://mlsanity.com/paper/2407.16697/) (2024)
- [From Pixel to Cancer: Cellular Automata in Computed Tomography](https://mlsanity.com/paper/2403.06459/) (2024)
- [Analyzing Tumors by Synthesis](https://mlsanity.com/paper/2409.06035/) (2024)
- [Memory-Assisted Sub-Prototype Mining for Universal Domain Adaptation](https://mlsanity.com/paper/2310.05453/) (2023)
- [RMSim: Controlled Respiratory Motion Simulation on Static Patient Scans](https://mlsanity.com/paper/2301.11422/) (2023)

## Built on by (most cited first, 2 of 2)

- [Are Video Models Ready as Zero-Shot Reasoners? An Empirical Study with the MME-CoF Benchmark](https://mlsanity.com/paper/2510.26802/) (2025)
- [In-Video Instructions: Visual Signals as Generative Control](https://mlsanity.com/paper/2511.19401/) (2025)

## Abstract (arXiv)

Recent advances in large generative models have shown that simple autoregressive formulations, when scaled appropriately, can exhibit strong zero-shot generalization across domains. Motivated by this trend, we investigate whether autoregressive video modeling principles can be directly applied to medical imaging tasks, despite the model never being trained on medical data. Specifically, we evaluate a large vision model (LVM) in a zero-shot setting across four representative tasks: organ segmentation, denoising, super-resolution, and motion prediction. Remarkably, even without domain-specific fine-tuning, the LVM can delineate anatomical structures in CT scans and achieve competitive performance on segmentation, denoising, and super-resolution. Most notably, in radiotherapy motion prediction, the model forecasts future 3D CT phases directly from prior phases of a 4D CT scan, producing anatomically consistent predictions that capture patient-specific respiratory dynamics with realistic temporal coherence. We evaluate the LVM on 4D CT data from 122 patients, totaling over 1,820 3D CT volumes. Despite no prior exposure to medical data, the model achieves strong performance across all tasks and surpasses specialized DVF-based and generative baselines in motion prediction, achieving state-of-the-art spatial accuracy. These findings reveal the emergence of zero-shot capabilities in medical video modeling and highlight the potential of general-purpose video models to serve as unified learners and reasoners laying the groundwork for future medical foundation models built on video models.