# Real-Time Health Analytics Using Ontology-Driven Complex Event Processing and LLM Reasoning: A Tuberculosis Case Study

arXiv: https://arxiv.org/abs/2510.09646 · HTML: https://mlsanity.com/paper/2510.09646/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 6 of its 22 references that are in the map.
- First posted on arXiv 5 Oct 2025.

## Builds on (most cited first, 6 of 6)

- [HealthQ: Unveiling Questioning Capabilities of LLM Chains in Healthcare Conversations](https://mlsanity.com/paper/2409.19487/) (2024)
- [Reasoning before Comparison: LLM-Enhanced Semantic Similarity Metrics for Domain Specialized Text Analysis](https://mlsanity.com/paper/2402.11398/) (2024)
- [OntoTune: Ontology-Driven Self-training for Aligning Large Language Models](https://mlsanity.com/paper/2502.05478/) (2025)
- [Ontology- and LLM-based Data Harmonization for Federated Learning in Healthcare](https://mlsanity.com/paper/2505.20020/) (2025)
- [Rule based Complex Event Processing for an Air Quality Monitoring System in Smart City](https://mlsanity.com/paper/2403.14701/) (2024)
- [OCEP: An Ontology-Based Complex Event Processing Framework for Healthcare Decision Support in Big Data Analytics](https://mlsanity.com/paper/2503.21453/) (2025)

## Abstract (arXiv)

Timely detection of critical health conditions remains a major challenge in public health analytics, especially in Big Data environments characterized by high volume, rapid velocity, and diverse variety of clinical data. This study presents an ontology-enabled real-time analytics framework that integrates Complex Event Processing (CEP) and Large Language Models (LLMs) to enable intelligent health event detection and semantic reasoning over heterogeneous, high-velocity health data streams. The architecture leverages the Basic Formal Ontology (BFO) and Semantic Web Rule Language (SWRL) to model diagnostic rules and domain knowledge. Patient data is ingested and processed using Apache Kafka and Spark Streaming, where CEP engines detect clinically significant event patterns. LLMs support adaptive reasoning, event interpretation, and ontology refinement. Clinical information is semantically structured as Resource Description Framework (RDF) triples in Graph DB, enabling SPARQL-based querying and knowledge-driven decision support. The framework is evaluated using a dataset of 1,000 Tuberculosis (TB) patients as a use case, demonstrating low-latency event detection, scalable reasoning, and high model performance (in terms of precision, recall, and F1-score). These results validate the system's potential for generalizable, real-time health analytics in complex Big Data scenarios.