# FedL2T: Personalized Federated Learning with Two-Teacher Distillation for Seizure Prediction

arXiv: https://arxiv.org/abs/2510.08984 · HTML: https://mlsanity.com/paper/2510.08984/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 11 of its 23 references that are in the map.
- First posted on arXiv 10 Oct 2025.

## Builds on (most cited first, 11 of 11)

- [Communication-Efficient Learning of Deep Networks from Decentralized Data](https://mlsanity.com/paper/1602.05629/) (2016)
- [FitNets: Hints for Thin Deep Nets](https://mlsanity.com/paper/1412.6550/) (2014)
- [MiniLM: Deep Self-Attention Distillation for Task-Agnostic Compression of Pre-Trained Transformers](https://mlsanity.com/paper/2002.10957/) (2020)
- [Ditto: Fair and Robust Federated Learning Through Personalization](https://mlsanity.com/paper/2012.04221/) (2020)
- [Deep Mutual Learning](https://mlsanity.com/paper/1706.00384/) (2017)
- [FedBN: Federated Learning on Non-IID Features via Local Batch Normalization](https://mlsanity.com/paper/2102.07623/) (2021)
- [Exploiting Shared Representations for Personalized Federated Learning](https://mlsanity.com/paper/2102.07078/) (2021)
- [FedKD: Communication Efficient Federated Learning via Knowledge Distillation](https://mlsanity.com/paper/2108.13323/) (2021)
- [Knowledge Distillation for Federated Learning: a Practical Guide](https://mlsanity.com/paper/2211.04742/) (2022)
- [Federated Model Heterogeneous Matryoshka Representation Learning](https://mlsanity.com/paper/2406.00488/) (2024)
- [PFLlib: A Beginner-Friendly and Comprehensive Personalized Federated Learning Library and Benchmark](https://mlsanity.com/paper/2312.04992/) (2023)

## Abstract (arXiv)

The training of deep learning models in seizure prediction requires large amounts of Electroencephalogram (EEG) data. However, acquiring sufficient labeled EEG data is difficult due to annotation costs and privacy constraints. Federated Learning (FL) enables privacy-preserving collaborative training by sharing model updates instead of raw data. However, due to the inherent inter-patient variability in real-world scenarios, existing FL-based seizure prediction methods struggle to achieve robust performance under heterogeneous client settings. To address this challenge, we propose FedL2T, a personalized federated learning framework that leverages a novel two-teacher knowledge distillation strategy to generate superior personalized models for each client. Specifically, each client simultaneously learns from a globally aggregated model and a dynamically assigned peer model, promoting more direct and enriched knowledge exchange. To ensure reliable knowledge transfer, FedL2T employs an adaptive multi-level distillation strategy that aligns both prediction outputs and intermediate feature representations based on task confidence. In addition, a proximal regularization term is introduced to constrain personalized model updates, thereby enhancing training stability. Extensive experiments on two EEG datasets demonstrate that FedL2T consistently outperforms state-of-the-art FL methods, particularly under low-label conditions. Moreover, FedL2T exhibits rapid and stable convergence toward optimal performance, thereby reducing the number of communication rounds and associated overhead. These results underscore the potential of FedL2T as a reliable and personalized solution for seizure prediction in privacy-sensitive healthcare scenarios.