# Self-Supervised Learning Strategies for a Platform to Test the Toxicity of New Chemicals and Materials

arXiv: https://arxiv.org/abs/2510.07853 · HTML: https://mlsanity.com/paper/2510.07853/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 20 of its 57 references that are in the map.
- First posted on arXiv 9 Oct 2025.

## Builds on (most cited first, 20 of 20)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
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- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Bootstrap your own latent: A new approach to self-supervised Learning](https://mlsanity.com/paper/2006.07733/) (2020)
- [UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction](https://mlsanity.com/paper/1802.03426/) (2018)
- [Exploring Simple Siamese Representation Learning](https://mlsanity.com/paper/2011.10566/) (2020)
- [Unsupervised Learning of Visual Features by Contrasting Cluster Assignments](https://mlsanity.com/paper/2006.09882/) (2020)
- [Improved Baselines with Momentum Contrastive Learning](https://mlsanity.com/paper/2003.04297/) (2020)
- [Survey of Hallucination in Natural Language Generation](https://mlsanity.com/paper/2202.03629/) (2022)
- [An Empirical Study of Training Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.02057/) (2021)
- [Understanding Contrastive Representation Learning through Alignment and Uniformity on the Hypersphere](https://mlsanity.com/paper/2005.10242/) (2020)
- [Unsupervised Learning of Visual Representations by Solving Jigsaw Puzzles](https://mlsanity.com/paper/1603.09246/) (2016)
- [Learning under Concept Drift: A Review](https://mlsanity.com/paper/2004.05785/) (2020)
- [One weird trick for parallelizing convolutional neural networks](https://mlsanity.com/paper/1404.5997/) (2014)
- [A Survey on Self-supervised Learning: Algorithms, Applications, and Future Trends](https://mlsanity.com/paper/2301.05712/) (2023)
- [EmbedTrack -- Simultaneous Cell Segmentation and Tracking Through Learning Offsets and Clustering Bandwidths](https://mlsanity.com/paper/2204.10713/) (2022)
- [MLOps for Scarce Image Data: A Use Case in Microscopic Image Analysis](https://mlsanity.com/paper/2309.15521/) (2023)

## Abstract (arXiv)

High-throughput toxicity testing offers a fast and cost-effective way to test large amounts of compounds. A key component for such systems is the automated evaluation via machine learning models. In this paper, we address critical challenges in this domain and demonstrate how representations learned via self-supervised learning can effectively identify toxicant-induced changes. We provide a proof-of-concept that utilizes the publicly available EmbryoNet dataset, which contains ten zebrafish embryo phenotypes elicited by various chemical compounds targeting different processes in early embryonic development. Our analysis shows that the learned representations using self-supervised learning are suitable for effectively distinguishing between the modes-of-action of different compounds. Finally, we discuss the integration of machine learning models in a physical toxicity testing device in the context of the TOXBOX project.