# EigenScore: OOD Detection using Covariance in Diffusion Models

arXiv: https://arxiv.org/abs/2510.07206 · HTML: https://mlsanity.com/paper/2510.07206/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 52 of its 71 references that are in the map.
- First posted on arXiv 8 Oct 2025.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 30 of 52)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Generative Modeling by Estimating Gradients of the Data Distribution](https://mlsanity.com/paper/1907.05600/) (2019)
- [Deep Learning Face Attributes in the Wild](https://mlsanity.com/paper/1411.7766/) (2014)
- [Elucidating the Design Space of Diffusion-Based Generative Models](https://mlsanity.com/paper/2206.00364/) (2022)
- [A Baseline for Detecting Misclassified and Out-of-Distribution Examples in Neural Networks](https://mlsanity.com/paper/1610.02136/) (2016)
- [Glow: Generative Flow with Invertible 1x1 Convolutions](https://mlsanity.com/paper/1807.03039/) (2018)
- [A Simple Unified Framework for Detecting Out-of-Distribution Samples and Adversarial Attacks](https://mlsanity.com/paper/1807.03888/) (2018)
- [Diffusion Posterior Sampling for General Noisy Inverse Problems](https://mlsanity.com/paper/2209.14687/) (2022)
- [WILDS: A Benchmark of in-the-Wild Distribution Shifts](https://mlsanity.com/paper/2012.07421/) (2020)
- [Energy-based Out-of-distribution Detection](https://mlsanity.com/paper/2010.03759/) (2020)
- [Diffusion Models: A Comprehensive Survey of Methods and Applications](https://mlsanity.com/paper/2209.00796/) (2022)
- [Diffusion Models in Vision: A Survey](https://mlsanity.com/paper/2209.04747/) (2022)
- [Generalized Out-of-Distribution Detection: A Survey](https://mlsanity.com/paper/2110.11334/) (2021)
- [Maximum Likelihood Training of Score-Based Diffusion Models](https://mlsanity.com/paper/2101.09258/) (2021)
- [Score-based Generative Modeling in Latent Space](https://mlsanity.com/paper/2106.05931/) (2021)
- [Using Self-Supervised Learning Can Improve Model Robustness and Uncertainty](https://mlsanity.com/paper/1906.12340/) (2019)
- [Likelihood Ratios for Out-of-Distribution Detection](https://mlsanity.com/paper/1906.02845/) (2019)
- [Do Deep Generative Models Know What They Don't Know?](https://mlsanity.com/paper/1810.09136/) (2018)
- [CSI: Novelty Detection via Contrastive Learning on Distributionally Shifted Instances](https://mlsanity.com/paper/2007.08176/) (2020)
- [PixelCNN++: Improving the PixelCNN with Discretized Logistic Mixture Likelihood and Other Modifications](https://mlsanity.com/paper/1701.05517/) (2017)
- [Diffusion Models for Medical Image Analysis: A Comprehensive Survey](https://mlsanity.com/paper/2211.07804/) (2022)
- [OpenOOD: Benchmarking Generalized Out-of-Distribution Detection](https://mlsanity.com/paper/2210.07242/) (2022)
- [Why Normalizing Flows Fail to Detect Out-of-Distribution Data](https://mlsanity.com/paper/2006.08545/) (2020)
- [Classification-Based Anomaly Detection for General Data](https://mlsanity.com/paper/2005.02359/) (2020)
- [Input complexity and out-of-distribution detection with likelihood-based generative models](https://mlsanity.com/paper/1909.11480/) (2019)
- [Generalization in diffusion models arises from geometry-adaptive harmonic representations](https://mlsanity.com/paper/2310.02557/) (2023)
- [A Survey on Diffusion Models for Inverse Problems](https://mlsanity.com/paper/2410.00083/) (2024)

## Built on by (most cited first, 4 of 4)

- [OSCAR: Orchestrated Self-verification and Cross-path Refinement](https://mlsanity.com/paper/2604.01624/) (2026)
- [GEPC: Group-Equivariant Posterior Consistency for Out-of-Distribution Detection in Diffusion Models](https://mlsanity.com/paper/2602.00191/) (2026)
- [Uncertainty-Aware Distribution-to-Distribution Flow Matching for Scientific Imaging](https://mlsanity.com/paper/2603.21717/) (2026)
- [KLIP: localized distribution shift detection via KL-divergence with diffusion priors in Inverse Problems](https://mlsanity.com/paper/2605.31596/) (2026)

## Abstract (arXiv)

Out-of-distribution (OOD) detection is critical for the safe deployment of machine learning systems in safety-sensitive domains. Diffusion models have recently emerged as powerful generative models, capable of capturing complex data distributions through iterative denoising. Building on this progress, recent work has explored their potential for OOD detection. We propose EigenScore, a new OOD detection method that leverages the eigenvalue spectrum of the posterior covariance induced by a diffusion model. We argue that posterior covariance provides a consistent signal of distribution shift, leading to larger trace and leading eigenvalues on OOD inputs, yielding a clear spectral signature. We further provide analysis explicitly linking posterior covariance to distribution mismatch, establishing it as a reliable signal for OOD detection. To ensure tractability, we adopt a Jacobian-free subspace iteration method to estimate the leading eigenvalues using only forward evaluations of the denoiser. Empirically, EigenScore achieves SOTA performance, with up to 5% AUROC improvement over the best baseline. Notably, it remains robust in near-OOD settings such as CIFAR-10 vs CIFAR-100, where existing diffusion-based methods often fail.