# Evolving and Executing Research Plans via Double-Loop Multi-Agent Collaboration

arXiv: https://arxiv.org/abs/2510.06761 · HTML: https://mlsanity.com/paper/2510.06761/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 16 of its 25 references that are in the map.
- First posted on arXiv 8 Oct 2025.

## Builds on (most cited first, 16 of 16)

- [The AI Scientist: Towards Fully Automated Open-Ended Scientific Discovery](https://mlsanity.com/paper/2408.06292/) (2024)
- [Agent Laboratory: Using LLM Agents as Research Assistants](https://mlsanity.com/paper/2501.04227/) (2025)
- [The AI Scientist-v2: Workshop-Level Automated Scientific Discovery via Agentic Tree Search](https://mlsanity.com/paper/2504.08066/) (2025)
- [Can LLMs Generate Novel Research Ideas? A Large-Scale Human Study with 100+ NLP Researchers](https://mlsanity.com/paper/2409.04109/) (2024)
- [PaperBench: Evaluating AI's Ability to Replicate AI Research](https://mlsanity.com/paper/2504.01848/) (2025)
- [SciMON: Scientific Inspiration Machines Optimized for Novelty](https://mlsanity.com/paper/2305.14259/) (2023)
- [CycleResearcher: Improving Automated Research via Automated Review](https://mlsanity.com/paper/2411.00816/) (2024)
- [Large Language Models for Automated Open-domain Scientific Hypotheses Discovery](https://mlsanity.com/paper/2309.02726/) (2023)
- [IdeaSynth: Iterative Research Idea Development Through Evolving and Composing Idea Facets with Literature-Grounded Feedback](https://mlsanity.com/paper/2410.04025/) (2024)
- [Dolphin: Moving Towards Closed-loop Auto-research through Thinking, Practice, and Feedback](https://mlsanity.com/paper/2501.03916/) (2025)
- [Bridging the Language Gaps in Large Language Models with Inference-Time Cross-Lingual Intervention](https://mlsanity.com/paper/2410.12462/) (2024)
- [A Computational Inflection for Scientific Discovery](https://mlsanity.com/paper/2205.02007/) (2022)
- [IRIS: Interactive Research Ideation System for Accelerating Scientific Discovery](https://mlsanity.com/paper/2504.16728/) (2025)
- [All That Glitters is Not Novel: Plagiarism in AI Generated Research](https://mlsanity.com/paper/2502.16487/) (2025)
- [ResearchCodeAgent: An LLM Multi-Agent System for Automated Codification of Research Methodologies](https://mlsanity.com/paper/2504.20117/) (2025)
- [LaTIM: Measuring Latent Token-to-Token Interactions in Mamba Models](https://mlsanity.com/paper/2502.15612/) (2025)

## Abstract (arXiv)

Automating the end-to-end scientific research process poses a fundamental challenge: it requires both evolving high-level plans that are novel and sound, and executing these plans correctly amidst dynamic and uncertain conditions. To address this bilevel challenge, we propose a novel Double-Loop Multi-Agent (DLMA) framework to solve the given research problem automatically. The leader loop, composed of professor agents, is responsible for evolving research plans. It employs an evolutionary algorithm through involvement, improvement, and integration meetings to iteratively generate and refine a pool of research proposals, exploring the solution space effectively. The follower loop, composed of doctoral student agents, is responsible for executing the best-evolved plan. It dynamically adjusts the plan during implementation via pre-hoc and post-hoc meetings, ensuring each step (e.g., drafting, coding) is well-supported by contextual and external observations. Extensive experiments on benchmarks like ACLAward and Laboratory show that DLMA generates research papers that achieve state-of-the-art scores in automated evaluation, significantly outperforming strong baselines. Ablation studies confirm the critical roles of both loops, with evolution driving novelty and execution ensuring soundness.