# Forecasting-based Biomedical Time-series Data Synthesis for Open Data and Robust AI

arXiv: https://arxiv.org/abs/2510.04622 · HTML: https://mlsanity.com/paper/2510.04622/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 26 of its 45 references that are in the map.
- First posted on arXiv 6 Oct 2025.

## Builds on (most cited first, 26 of 26)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Deep Learning with Differential Privacy](https://mlsanity.com/paper/1607.00133/) (2016)
- [A Time Series is Worth 64 Words: Long-term Forecasting with Transformers](https://mlsanity.com/paper/2211.14730/) (2022)
- [An Empirical Evaluation of Generic Convolutional and Recurrent Networks for Sequence Modeling](https://mlsanity.com/paper/1803.01271/) (2018)
- [Are Transformers Effective for Time Series Forecasting?](https://mlsanity.com/paper/2205.13504/) (2022)
- [TimesNet: Temporal 2D-Variation Modeling for General Time Series Analysis](https://mlsanity.com/paper/2210.02186/) (2022)
- [DeepAR: Probabilistic Forecasting with Autoregressive Recurrent Networks](https://mlsanity.com/paper/1704.04110/) (2017)
- [iTransformer: Inverted Transformers Are Effective for Time Series Forecasting](https://mlsanity.com/paper/2310.06625/) (2023)
- [Temporal Fusion Transformers for Interpretable Multi-horizon Time Series Forecasting](https://mlsanity.com/paper/1912.09363/) (2019)
- [N-BEATS: Neural basis expansion analysis for interpretable time series forecasting](https://mlsanity.com/paper/1905.10437/) (2019)
- [KAN: Kolmogorov-Arnold Networks](https://mlsanity.com/paper/2404.19756/) (2024)
- [CSDI: Conditional Score-based Diffusion Models for Probabilistic Time Series Imputation](https://mlsanity.com/paper/2107.03502/) (2021)
- [Real-valued (Medical) Time Series Generation with Recurrent Conditional GANs](https://mlsanity.com/paper/1706.02633/) (2017)
- [Long-term Forecasting with TiDE: Time-series Dense Encoder](https://mlsanity.com/paper/2304.08424/) (2023)
- [N-HiTS: Neural Hierarchical Interpolation for Time Series Forecasting](https://mlsanity.com/paper/2201.12886/) (2022)
- [TimeVAE: A Variational Auto-Encoder for Multivariate Time Series Generation](https://mlsanity.com/paper/2111.08095/) (2021)
- [Dilated Recurrent Neural Networks](https://mlsanity.com/paper/1710.02224/) (2017)
- [SOFTS: Efficient Multivariate Time Series Forecasting with Series-Core Fusion](https://mlsanity.com/paper/2404.14197/) (2024)
- [Towards Generalizable Tumor Synthesis](https://mlsanity.com/paper/2402.19470/) (2024)
- [Neural basis expansion analysis with exogenous variables: Forecasting electricity prices with NBEATSx](https://mlsanity.com/paper/2104.05522/) (2021)
- [Vector Quantized Time Series Generation with a Bidirectional Prior Model](https://mlsanity.com/paper/2303.04743/) (2023)
- [An Alternative Probabilistic Interpretation of the Huber Loss](https://mlsanity.com/paper/1911.02088/) (2019)
- [Time Weaver: A Conditional Time Series Generation Model](https://mlsanity.com/paper/2403.02682/) (2024)
- [Universal Time-Series Representation Learning: A Survey](https://mlsanity.com/paper/2401.03717/) (2024)
- [Parameter Efficient Deep Probabilistic Forecasting](https://mlsanity.com/paper/2112.02905/) (2021)
- [Structured Evaluation of Synthetic Tabular Data](https://mlsanity.com/paper/2403.10424/) (2024)

## Abstract (arXiv)

The limited data availability due to strict privacy regulations and significant resource demands severely constrains biomedical time-series AI development, which creates a critical gap between data requirements and accessibility. Synthetic data generation presents a promising solution by producing artificial datasets that maintain the statistical properties of real biomedical time-series data without compromising patient confidentiality. While GANs, VAEs, and diffusion models capture global data distributions, forecasting models offer inductive biases tailored for sequential dynamics. We propose a framework for synthetic biomedical time-series data generation based on recent forecasting models that accurately replicates complex electrophysiological signals such as EEG and EMG with high fidelity. These synthetic datasets can be freely shared for open AI development and consistently improve downstream model performance. Numerical results on sleep-stage classification show up to a 3.71% performance gain with augmentation and a 91.00% synthetic-only accuracy that surpasses the real-data-only baseline.