# Cross-Lingual Multi-Granularity Framework for Interpretable Parkinson's Disease Diagnosis from Speech

arXiv: https://arxiv.org/abs/2510.03758 · HTML: https://mlsanity.com/paper/2510.03758/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 5 of its 20 references that are in the map.
- First posted on arXiv 4 Oct 2025.

## Builds on (most cited first, 5 of 5)

- [Robust Speech Recognition via Large-Scale Weak Supervision](https://mlsanity.com/paper/2212.04356/) (2022)
- [wav2vec 2.0: A Framework for Self-Supervised Learning of Speech Representations](https://mlsanity.com/paper/2006.11477/) (2020)
- [WhisperX: Time-Accurate Speech Transcription of Long-Form Audio](https://mlsanity.com/paper/2303.00747/) (2023)
- [NeuroVoz: a Castillian Spanish corpus of parkinsonian speech](https://mlsanity.com/paper/2403.02371/) (2024)
- [The Phonetic Footprint of Parkinson's Disease](https://mlsanity.com/paper/2112.11514/) (2021)

## Abstract (arXiv)

Parkinson's Disease (PD) affects over 10 million people worldwide, with speech impairments in up to 89% of patients. Current speech-based detection systems analyze entire utterances, potentially overlooking the diagnostic value of specific phonetic elements. We developed a granularity-aware approach for multilingual PD detection using an automated pipeline that extracts time-aligned phonemes, syllables, and words from recordings. Using Italian, Spanish, and English datasets, we implemented a bidirectional LSTM with multi-head attention to compare diagnostic performance across the different granularity levels. Phoneme-level analysis achieved superior performance with AUROC of 93.78% +- 2.34% and accuracy of 92.17% +- 2.43%. This demonstrates enhanced diagnostic capability for cross-linguistic PD detection. Importantly, attention analysis revealed that the most informative speech features align with those used in established clinical protocols: sustained vowels (/a/, /e/, /o/, /i/) at phoneme level, diadochokinetic syllables (/ta/, /pa/, /la/, /ka/) at syllable level, and /pataka/ sequences at word level. Source code will be available at https://github.com/jetliqs/clearpd.