# Interpretable Neuropsychiatric Diagnosis via Concept-Guided Graph Neural Networks

arXiv: https://arxiv.org/abs/2510.03351 · HTML: https://mlsanity.com/paper/2510.03351/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 22 of its 43 references that are in the map.
- First posted on arXiv 2 Oct 2025.

## Builds on (most cited first, 22 of 22)

- [Semi-Supervised Classification with Graph Convolutional Networks](https://mlsanity.com/paper/1609.02907/) (2016)
- [Graph Attention Networks](https://mlsanity.com/paper/1710.10903/) (2017)
- [How Powerful are Graph Neural Networks?](https://mlsanity.com/paper/1810.00826/) (2018)
- [Interpretability Beyond Feature Attribution: Quantitative Testing with Concept Activation Vectors (TCAV)](https://mlsanity.com/paper/1711.11279/) (2017)
- [Concept Bottleneck Models](https://mlsanity.com/paper/2007.04612/) (2020)
- [Language in a Bottle: Language Model Guided Concept Bottlenecks for Interpretable Image Classification](https://mlsanity.com/paper/2211.11158/) (2022)
- [On Completeness-aware Concept-Based Explanations in Deep Neural Networks](https://mlsanity.com/paper/1910.07969/) (2019)
- [GraphLIME: Local Interpretable Model Explanations for Graph Neural Networks](https://mlsanity.com/paper/2001.06216/) (2020)
- [Brain Network Transformer](https://mlsanity.com/paper/2210.06681/) (2022)
- [BrainGB: A Benchmark for Brain Network Analysis with Graph Neural Networks](https://mlsanity.com/paper/2204.07054/) (2022)
- [NeuroGraph: Benchmarks for Graph Machine Learning in Brain Connectomics](https://mlsanity.com/paper/2306.06202/) (2023)
- [Global Concept-Based Interpretability for Graph Neural Networks via Neuron Analysis](https://mlsanity.com/paper/2208.10609/) (2022)
- [Deep Learning in Alzheimer's disease: Diagnostic Classification and Prognostic Prediction using Neuroimaging Data](https://mlsanity.com/paper/1905.00931/) (2019)
- [ASD-DiagNet: A hybrid learning approach for detection of Autism Spectrum Disorder using fMRI data](https://mlsanity.com/paper/1904.07577/) (2019)
- [Graph Few-shot Learning with Task-specific Structures](https://mlsanity.com/paper/2210.12130/) (2022)
- [Concept Bottleneck with Visual Concept Filtering for Explainable Medical Image Classification](https://mlsanity.com/paper/2308.11920/) (2023)
- [Data-Efficient Brain Connectome Analysis via Multi-Task Meta-Learning](https://mlsanity.com/paper/2206.04486/) (2022)
- [Integrated Brain Connectivity Analysis with fMRI, DTI, and sMRI Powered by Interpretable Graph Neural Networks](https://mlsanity.com/paper/2408.14254/) (2024)
- [NeuroQuery: comprehensive meta-analysis of human brain mapping](https://mlsanity.com/paper/2002.09261/) (2020)
- [Coupling Artificial Neurons in BERT and Biological Neurons in the Human Brain](https://mlsanity.com/paper/2303.14871/) (2023)
- [Graph Concept Bottleneck Models](https://mlsanity.com/paper/2508.14255/) (2025)
- [Joint Learning Neuronal Skeleton and Brain Circuit Topology with Permutation Invariant Encoders for Neuron Classification](https://mlsanity.com/paper/2312.14518/) (2023)

## Built on by (most cited first, 1 of 1)

- [MolLedger: An Additive Graph Neural Network with Chemically Grounded ADME Attributions](https://mlsanity.com/paper/2608.30636/) (2026)

## Abstract (arXiv)

Nearly one in five adolescents currently live with a diagnosed mental or behavioral health condition, such as anxiety, depression, or conduct disorder, underscoring the urgency of developing accurate and interpretable diagnostic tools. Resting-state functional magnetic resonance imaging (rs-fMRI) provides a powerful lens into large-scale functional connectivity, where brain regions are modeled as nodes and inter-regional synchrony as edges, offering clinically relevant biomarkers for psychiatric disorders. While prior works use graph neural network (GNN) approaches for disorder prediction, they remain complex black-boxes, limiting their reliability and clinical translation. In this work, we propose CONCEPTNEURO, a concept-based diagnosis framework that leverages large language models (LLMs) and neurobiological domain knowledge to automatically generate, filter, and encode interpretable functional connectivity concepts. Each concept is represented as a structured subgraph linking specific brain regions, which are then passed through a concept classifier. Our design ensures predictions through clinically meaningful connectivity patterns, enabling both interpretability and strong predictive performance. Extensive experiments across multiple psychiatric disorder datasets demonstrate that CONCEPTNEURO-augmented GNNs consistently outperform their vanilla counterparts, improving accuracy while providing transparent, clinically aligned explanations. Furthermore, concept analyses highlight disorder-specific connectivity patterns that align with expert knowledge and suggest new hypotheses for future investigation, establishing CONCEPTNEURO as an interpretable, domain-informed framework for psychiatric disorder diagnosis.