# Hierarchical Generalized Category Discovery for Brain Tumor Classification in Digital Pathology

arXiv: https://arxiv.org/abs/2510.02760 · HTML: https://mlsanity.com/paper/2510.02760/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 17 of its 41 references that are in the map.
- First posted on arXiv 3 Oct 2025.

## Builds on (most cited first, 17 of 17)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Generalized Category Discovery](https://mlsanity.com/paper/2201.02609/) (2022)
- [Multimodal Whole Slide Foundation Model for Pathology](https://mlsanity.com/paper/2411.19666/) (2024)
- [Dynamic Conceptional Contrastive Learning for Generalized Category Discovery](https://mlsanity.com/paper/2303.17393/) (2023)
- [PromptCAL: Contrastive Affinity Learning via Auxiliary Prompts for Generalized Novel Category Discovery](https://mlsanity.com/paper/2212.05590/) (2022)
- [Accelerating Data Processing and Benchmarking of AI Models for Pathology](https://mlsanity.com/paper/2502.06750/) (2025)
- [MetaGCD: Learning to Continually Learn in Generalized Category Discovery](https://mlsanity.com/paper/2308.11063/) (2023)
- [Learn to Categorize or Categorize to Learn? Self-Coding for Generalized Category Discovery](https://mlsanity.com/paper/2310.19776/) (2023)
- [SelEx: Self-Expertise in Fine-Grained Generalized Category Discovery](https://mlsanity.com/paper/2408.14371/) (2024)
- [Active Generalized Category Discovery](https://mlsanity.com/paper/2403.04272/) (2024)
- [CiPR: An Efficient Framework with Cross-instance Positive Relations for Generalized Category Discovery](https://mlsanity.com/paper/2304.06928/) (2023)
- [Incremental Generalized Category Discovery](https://mlsanity.com/paper/2304.14310/) (2023)
- [DebGCD: Debiased Learning with Distribution Guidance for Generalized Category Discovery](https://mlsanity.com/paper/2504.04804/) (2025)
- [Seeing Unseen: Discover Novel Biomedical Concepts via Geometry-Constrained Probabilistic Modeling](https://mlsanity.com/paper/2403.01053/) (2024)
- [OpenSRH: optimizing brain tumor surgery using intraoperative stimulated Raman histology](https://mlsanity.com/paper/2206.08439/) (2022)

## Abstract (arXiv)

Accurate brain tumor classification is critical for intra-operative decision making in neuro-oncological surgery. However, existing approaches are restricted to a fixed set of predefined classes and are therefore unable to capture patterns of tumor types not available during training. Unsupervised learning can extract general-purpose features, but it lacks the ability to incorporate prior knowledge from labelled data, and semi-supervised methods often assume that all potential classes are represented in the labelled data. Generalized Category Discovery (GCD) aims to bridge this gap by categorizing both known and unknown classes within unlabelled data. To reflect the hierarchical structure of brain tumor taxonomies, in this work, we introduce Hierarchical Generalized Category Discovery for Brain Tumor Classification (HGCD-BT), a novel approach that integrates hierarchical clustering with contrastive learning. Our method extends contrastive learning based GCD by incorporating a novel semi-supervised hierarchical clustering loss. We evaluate HGCD-BT on OpenSRH, a dataset of stimulated Raman histology brain tumor images, achieving a +28% improvement in accuracy over state-of-the-art GCD methods for patch-level classification, particularly in identifying previously unseen tumor categories. Furthermore, we demonstrate the generalizability of HGCD-BT on slide-level classification of hematoxylin and eosin stained whole-slide images from the Digital Brain Tumor Atlas, confirming its utility across imaging modalities.