# Tumor Synthesis conditioned on Radiomics

arXiv: https://arxiv.org/abs/2509.24182 · HTML: https://mlsanity.com/paper/2509.24182/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 53 of its 82 references that are in the map.
- First posted on arXiv 29 Sep 2025.

## Builds on (most cited first, 30 of 53)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Taming Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2012.09841/) (2020)
- [Make-A-Video: Text-to-Video Generation without Text-Video Data](https://mlsanity.com/paper/2209.14792/) (2022)
- [Image Super-Resolution via Iterative Refinement](https://mlsanity.com/paper/2104.07636/) (2021)
- [Align your Latents: High-Resolution Video Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2304.08818/) (2023)
- [RePaint: Inpainting using Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2201.09865/) (2022)
- [Palette: Image-to-Image Diffusion Models](https://mlsanity.com/paper/2111.05826/) (2021)
- [Cascaded Diffusion Models for High Fidelity Image Generation](https://mlsanity.com/paper/2106.15282/) (2021)
- [Diffusion Models: A Comprehensive Survey of Methods and Applications](https://mlsanity.com/paper/2209.00796/) (2022)
- [StyleCLIP: Text-Driven Manipulation of StyleGAN Imagery](https://mlsanity.com/paper/2103.17249/) (2021)
- [Tune-A-Video: One-Shot Tuning of Image Diffusion Models for Text-to-Video Generation](https://mlsanity.com/paper/2212.11565/) (2022)
- [Multimodal Unsupervised Image-to-Image Translation](https://mlsanity.com/paper/1804.04732/) (2018)
- [Generative Adversarial Text to Image Synthesis](https://mlsanity.com/paper/1605.05396/) (2016)
- [AttnGAN: Fine-Grained Text to Image Generation with Attentional Generative Adversarial Networks](https://mlsanity.com/paper/1711.10485/) (2017)
- [StackGAN: Text to Photo-realistic Image Synthesis with Stacked Generative Adversarial Networks](https://mlsanity.com/paper/1612.03242/) (2016)
- [The RSNA-ASNR-MICCAI BraTS 2021 Benchmark on Brain Tumor Segmentation and Radiogenomic Classification](https://mlsanity.com/paper/2107.02314/) (2021)
- [Scaling up GANs for Text-to-Image Synthesis](https://mlsanity.com/paper/2303.05511/) (2023)
- [Deep Learning for Medical Image Analysis](https://mlsanity.com/paper/1708.08987/) (2017)
- [ResShift: Efficient Diffusion Model for Image Super-resolution by Residual Shifting](https://mlsanity.com/paper/2307.12348/) (2023)

## Built on by (most cited first, 1 of 1)

- [Auditing Sybil: Explaining Deep Lung Cancer Risk Prediction Through Generative Interventional Attributions](https://mlsanity.com/paper/2602.02560/) (2026)

## Abstract (arXiv)

Due to privacy concerns, obtaining large datasets is challenging in medical image analysis, especially with 3D modalities like Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Existing generative models, developed to address this issue, often face limitations in output diversity and thus cannot accurately represent 3D medical images. We propose a tumor-generation model that utilizes radiomics features as generative conditions. Radiomics features are high-dimensional handcrafted semantic features that are biologically well-grounded and thus are good candidates for conditioning. Our model employs a GAN-based model to generate tumor masks and a diffusion-based approach to generate tumor texture conditioned on radiomics features. Our method allows the user to generate tumor images according to user-specified radiomics features such as size, shape, and texture at an arbitrary location. This enables the physicians to easily visualize tumor images to better understand tumors according to changing radiomics features. Our approach allows for the removal, manipulation, and repositioning of tumors, generating various tumor types in different scenarios. The model has been tested on tumors in four different organs (kidney, lung, breast, and brain) across CT and MRI. The synthesized images are shown to effectively aid in training for downstream tasks and their authenticity was also evaluated through expert evaluations. Our method has potential usage in treatment planning with diverse synthesized tumors.