# Region-of-Interest Augmentation for Mammography Classification under Patient-Level Cross-Validation

arXiv: https://arxiv.org/abs/2509.20585 · HTML: https://mlsanity.com/paper/2509.20585/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 31 references that are in the map.
- First posted on arXiv 24 Sep 2025.

## Builds on (most cited first, 9 of 9)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [A Survey on Deep Learning in Medical Image Analysis](https://mlsanity.com/paper/1702.05747/) (2017)
- [Mixed Precision Training](https://mlsanity.com/paper/1710.03740/) (2017)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [Attention Gated Networks: Learning to Leverage Salient Regions in Medical Images](https://mlsanity.com/paper/1808.08114/) (2018)
- [Common pitfalls and recommendations for using machine learning to detect and prognosticate for COVID-19 using chest radiographs and CT scans](https://mlsanity.com/paper/2008.06388/) (2020)
- [End-to-end Training for Whole Image Breast Cancer Diagnosis using An All Convolutional Design](https://mlsanity.com/paper/1711.05775/) (2017)
- [High-Resolution Breast Cancer Screening with Multi-View Deep Convolutional Neural Networks](https://mlsanity.com/paper/1703.07047/) (2017)

## Abstract (arXiv)

Breast cancer screening with mammography remains central to early detection and mortality reduction. Deep learning has shown strong potential for automating mammogram interpretation, yet limited-resolution datasets and small sample sizes continue to restrict performance. We revisit the Mini-DDSM dataset (9,684 images; 2,414 patients) and introduce a lightweight region-of-interest (ROI) augmentation strategy. During training, full images are probabilistically replaced with random ROI crops sampled from a precomputed, label-free bounding-box bank, with optional jitter to increase variability. We evaluate under strict patient-level cross-validation and report ROC-AUC, PR-AUC, and training-time efficiency metrics (throughput and GPU memory). Because ROI augmentation is training-only, inference-time cost remains unchanged. On Mini-DDSM, ROI augmentation (best: p_roi = 0.10, alpha = 0.10) yields modest average ROC-AUC gains, with performance varying across folds; PR-AUC is flat to slightly lower. These results demonstrate that simple, data-centric ROI strategies can enhance mammography classification in constrained settings without requiring additional labels or architectural modifications.