# Multimodal Medical Image Classification via Synergistic Learning Pre-training

arXiv: https://arxiv.org/abs/2509.17492 · HTML: https://mlsanity.com/paper/2509.17492/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 19 of its 38 references that are in the map.
- First posted on arXiv 22 Sep 2025.

## Builds on (most cited first, 19 of 19)

- [Representation Learning with Contrastive Predictive Coding](https://mlsanity.com/paper/1807.03748/) (2018)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [mixup: Beyond Empirical Risk Minimization](https://mlsanity.com/paper/1710.09412/) (2017)
- [RandAugment: Practical automated data augmentation with a reduced search space](https://mlsanity.com/paper/1909.13719/) (2019)
- [FixMatch: Simplifying Semi-Supervised Learning with Consistency and Confidence](https://mlsanity.com/paper/2001.07685/) (2020)
- [Align before Fuse: Vision and Language Representation Learning with Momentum Distillation](https://mlsanity.com/paper/2107.07651/) (2021)
- [FlexMatch: Boosting Semi-Supervised Learning with Curriculum Pseudo Labeling](https://mlsanity.com/paper/2110.08263/) (2021)
- [FreeMatch: Self-adaptive Thresholding for Semi-supervised Learning](https://mlsanity.com/paper/2205.07246/) (2022)
- [Trusted Multi-View Classification with Dynamic Evidential Fusion](https://mlsanity.com/paper/2204.11423/) (2022)
- [Dash: Semi-Supervised Learning with Dynamic Thresholding](https://mlsanity.com/paper/2109.00650/) (2021)
- [SoftMatch: Addressing the Quantity-Quality Trade-off in Semi-supervised Learning](https://mlsanity.com/paper/2301.10921/) (2023)
- [SimMatch: Semi-supervised Learning with Similarity Matching](https://mlsanity.com/paper/2203.06915/) (2022)
- [TGFuse: An Infrared and Visible Image Fusion Approach Based on Transformer and Generative Adversarial Network](https://mlsanity.com/paper/2201.10147/) (2022)
- [Anatomical Structure-Guided Medical Vision-Language Pre-training](https://mlsanity.com/paper/2403.09294/) (2024)
- [Towards better understanding and better generalization of few-shot classification in histology images with contrastive learning](https://mlsanity.com/paper/2202.09059/) (2022)
- [Deep Multimodal Guidance for Medical Image Classification](https://mlsanity.com/paper/2203.05683/) (2022)
- [Gene-induced Multimodal Pre-training for Image-omic Classification](https://mlsanity.com/paper/2309.02702/) (2023)
- [SIAVC: Semi-Supervised Framework for Industrial Accident Video Classification](https://mlsanity.com/paper/2405.14506/) (2024)

## Abstract (arXiv)

Multimodal pathological images are usually in clinical diagnosis, but computer vision-based multimodal image-assisted diagnosis faces challenges with modality fusion, especially in the absence of expert-annotated data. To achieve the modality fusion in multimodal images with label scarcity, we propose a novel ``pretraining + fine-tuning" framework for multimodal semi-supervised medical image classification. Specifically, we propose a synergistic learning pretraining framework of consistency, reconstructive, and aligned learning. By treating one modality as an augmented sample of another modality, we implement a self-supervised learning pre-train, enhancing the baseline model's feature representation capability. Then, we design a fine-tuning method for multimodal fusion. During the fine-tuning stage, we set different encoders to extract features from the original modalities and provide a multimodal fusion encoder for fusion modality. In addition, we propose a distribution shift method for multimodal fusion features, which alleviates the prediction uncertainty and overfitting risks caused by the lack of labeled samples. We conduct extensive experiments on the publicly available gastroscopy image datasets Kvasir and Kvasirv2. Quantitative and qualitative results demonstrate that the proposed method outperforms the current state-of-the-art classification methods. The code will be released at: https://github.com/LQH89757/MICS.