# A Unified AI Approach for Continuous Monitoring of Human Health and Diseases from Intensive Care Unit to Home with Physiological Foundation Models (UNIPHY+)

arXiv: https://arxiv.org/abs/2509.16348 · HTML: https://mlsanity.com/paper/2509.16348/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 14 of its 37 references that are in the map.
- First posted on arXiv 19 Sep 2025.

## Builds on (most cited first, 14 of 14)

- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [On the Opportunities and Risks of Foundation Models](https://mlsanity.com/paper/2108.07258/) (2021)
- [A Time Series is Worth 64 Words: Long-term Forecasting with Transformers](https://mlsanity.com/paper/2211.14730/) (2022)
- [Knowledge Distillation: A Survey](https://mlsanity.com/paper/2006.05525/) (2020)
- [Chronos: Learning the Language of Time Series](https://mlsanity.com/paper/2403.07815/) (2024)
- [Gated Multimodal Units for Information Fusion](https://mlsanity.com/paper/1702.01992/) (2017)
- [Adversarial Reprogramming of Neural Networks](https://mlsanity.com/paper/1806.11146/) (2018)
- [Self-Supervised Transformer for Sparse and Irregularly Sampled Multivariate Clinical Time-Series](https://mlsanity.com/paper/2107.14293/) (2021)
- [Large-scale Training of Foundation Models for Wearable Biosignals](https://mlsanity.com/paper/2312.05409/) (2023)
- [Guiding Masked Representation Learning to Capture Spatio-Temporal Relationship of Electrocardiogram](https://mlsanity.com/paper/2402.09450/) (2024)
- [Self-supervised representation learning from 12-lead ECG data](https://mlsanity.com/paper/2103.12676/) (2021)
- [PaPaGei: Open Foundation Models for Optical Physiological Signals](https://mlsanity.com/paper/2410.20542/) (2024)
- [LightTS: Lightweight Time Series Classification with Adaptive Ensemble Distillation -- Extended Version](https://mlsanity.com/paper/2302.12721/) (2023)
- [Pulse-PPG: An Open-Source Field-Trained PPG Foundation Model for Wearable Applications Across Lab and Field Settings](https://mlsanity.com/paper/2502.01108/) (2025)

## Built on by (most cited first, 2 of 2)

- [Generalist vs Specialist Time Series Foundation Models: Investigating Potential Emergent Behaviors in Assessing Human Health Using PPG Signals](https://mlsanity.com/paper/2510.14254/) (2025)
- [Exposing Vulnerabilities in Explanation for Time Series Classifiers via Dual-Target Attacks](https://mlsanity.com/paper/2602.02763/) (2026)

## Abstract (arXiv)

We present UNIPHY+, a unified physiological foundation model (physioFM) framework designed to enable continuous human health and diseases monitoring across care settings using ubiquitously obtainable physiological data. We propose novel strategies for incorporating contextual information during pretraining, fine-tuning, and lightweight model personalization via multi-modal learning, feature fusion-tuning, and knowledge distillation. We advocate testing UNIPHY+ with a broad set of use cases from intensive care to ambulatory monitoring in order to demonstrate that UNIPHY+ can empower generalizable, scalable, and personalized physiological AI to support both clinical decision-making and long-term health monitoring.