# Blind-Spot Guided Diffusion for Self-supervised Real-World Denoising

arXiv: https://arxiv.org/abs/2509.16091 · HTML: https://mlsanity.com/paper/2509.16091/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Placed in Diffusion foundations and sampling, one of 14 directions in Diffusion models.
- Builds on 51 of its 64 references that are in the map.
- First posted on arXiv 19 Sep 2025.

## Placed in

- Diffusion models / [Diffusion foundations and sampling](https://mlsanity.com/diffusion/diffusion-foundations-and-sampling/)

## Builds on (most cited first, 30 of 51)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [Beyond a Gaussian Denoiser: Residual Learning of Deep CNN for Image Denoising](https://mlsanity.com/paper/1608.03981/) (2016)
- [Deep Image Prior](https://mlsanity.com/paper/1711.10925/) (2017)
- [Zero-Shot Image Restoration Using Denoising Diffusion Null-Space Model](https://mlsanity.com/paper/2212.00490/) (2022)
- [Noise2Noise: Learning Image Restoration without Clean Data](https://mlsanity.com/paper/1803.04189/) (2018)
- [FFDNet: Toward a Fast and Flexible Solution for CNN based Image Denoising](https://mlsanity.com/paper/1710.04026/) (2017)
- [Learning Deep CNN Denoiser Prior for Image Restoration](https://mlsanity.com/paper/1704.03264/) (2017)
- [Noise2Void - Learning Denoising from Single Noisy Images](https://mlsanity.com/paper/1811.10980/) (2018)
- [DiffusionDet: Diffusion Model for Object Detection](https://mlsanity.com/paper/2211.09788/) (2022)
- [Repurposing Diffusion-Based Image Generators for Monocular Depth Estimation](https://mlsanity.com/paper/2312.02145/) (2023)
- [Learning Enriched Features for Real Image Restoration and Enhancement](https://mlsanity.com/paper/2003.06792/) (2020)
- [Noise2Self: Blind Denoising by Self-Supervision](https://mlsanity.com/paper/1901.11365/) (2019)
- [Toward Convolutional Blind Denoising of Real Photographs](https://mlsanity.com/paper/1807.04686/) (2018)
- [MemNet: A Persistent Memory Network for Image Restoration](https://mlsanity.com/paper/1708.02209/) (2017)
- [Implicit Diffusion Models for Continuous Super-Resolution](https://mlsanity.com/paper/2303.16491/) (2023)
- [Benchmarking Denoising Algorithms with Real Photographs](https://mlsanity.com/paper/1707.01313/) (2017)
- [Trainable Nonlinear Reaction Diffusion: A Flexible Framework for Fast and Effective Image Restoration](https://mlsanity.com/paper/1508.02848/) (2015)
- [Neighbor2Neighbor: Self-Supervised Denoising from Single Noisy Images](https://mlsanity.com/paper/2101.02824/) (2021)
- [High-Quality Self-Supervised Deep Image Denoising](https://mlsanity.com/paper/1901.10277/) (2019)
- [Low-Light Image Enhancement with Wavelet-based Diffusion Models](https://mlsanity.com/paper/2306.00306/) (2023)
- [The Surprising Effectiveness of Diffusion Models for Optical Flow and Monocular Depth Estimation](https://mlsanity.com/paper/2306.01923/) (2023)
- [Dual Adversarial Network: Toward Real-world Noise Removal and Noise Generation](https://mlsanity.com/paper/2007.05946/) (2020)
- [Coherent Semantic Attention for Image Inpainting](https://mlsanity.com/paper/1905.12384/) (2019)
- [AP-BSN: Self-Supervised Denoising for Real-World Images via Asymmetric PD and Blind-Spot Network](https://mlsanity.com/paper/2203.11799/) (2022)
- [NBNet: Noise Basis Learning for Image Denoising with Subspace Projection](https://mlsanity.com/paper/2012.15028/) (2020)

## Built on by (most cited first, 2 of 2)

- [ExpoCM: Exposure-Aware One-Step Generative Single-Image HDR Reconstruction](https://mlsanity.com/paper/2605.02464/) (2026)
- [ZeroIDIR: Zero-Reference Illumination Degradation Image Restoration with Perturbed Consistency Diffusion Models](https://mlsanity.com/paper/2605.11435/) (2026)

## Abstract (arXiv)

In this work, we present Blind-Spot Guided Diffusion, a novel self-supervised framework for real-world image denoising. Our approach addresses two major challenges: the limitations of blind-spot networks (BSNs), which often sacrifice local detail and introduce pixel discontinuities due to spatial independence assumptions, and the difficulty of adapting diffusion models to self-supervised denoising. We propose a dual-branch diffusion framework that combines a BSN-based diffusion branch, generating semi-clean images, with a conventional diffusion branch that captures underlying noise distributions. To enable effective training without paired data, we use the BSN-based branch to guide the sampling process, capturing noise structure while preserving local details. Extensive experiments on the SIDD and DND datasets demonstrate state-of-the-art performance, establishing our method as a highly effective self-supervised solution for real-world denoising. Code and pre-trained models are released at: https://github.com/Sumching/BSGD.