# pFedSAM: Personalized Federated Learning of Segment Anything Model for Medical Image Segmentation

arXiv: https://arxiv.org/abs/2509.15638 · HTML: https://mlsanity.com/paper/2509.15638/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Medical and biomedical MoE, one of 12 directions in Mixture-of-experts.
- Builds on 16 of its 23 references that are in the map.
- First posted on arXiv 19 Sep 2025.

## Placed in

- Mixture-of-experts / [Medical and biomedical MoE](https://mlsanity.com/moe/medical-and-biomedical-moe/)
- Knowledge distillation / [Distillation for medical imaging](https://mlsanity.com/distill/distillation-for-medical-imaging/)

## Builds on (most cited first, 16 of 16)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [Communication-Efficient Learning of Deep Networks from Decentralized Data](https://mlsanity.com/paper/1602.05629/) (2016)
- [Ditto: Fair and Robust Federated Learning Through Personalization](https://mlsanity.com/paper/2012.04221/) (2020)
- [Personalized Federated Learning with Moreau Envelopes](https://mlsanity.com/paper/2006.08848/) (2020)
- [FedBN: Federated Learning on Non-IID Features via Local Batch Normalization](https://mlsanity.com/paper/2102.07623/) (2021)
- [Federated Learning on Non-IID Data Silos: An Experimental Study](https://mlsanity.com/paper/2102.02079/) (2021)
- [Federated Learning with Personalization Layers](https://mlsanity.com/paper/1912.00818/) (2019)
- [Medical SAM Adapter: Adapting Segment Anything Model for Medical Image Segmentation](https://mlsanity.com/paper/2304.12620/) (2023)
- [REFUGE Challenge: A Unified Framework for Evaluating Automated Methods for Glaucoma Assessment from Fundus Photographs](https://mlsanity.com/paper/1910.03667/) (2019)
- [Convolution Meets LoRA: Parameter Efficient Finetuning for Segment Anything Model](https://mlsanity.com/paper/2401.17868/) (2024)
- [G1020: A Benchmark Retinal Fundus Image Dataset for Computer-Aided Glaucoma Detection](https://mlsanity.com/paper/2006.09158/) (2020)
- [FedFMS: Exploring Federated Foundation Models for Medical Image Segmentation](https://mlsanity.com/paper/2403.05408/) (2024)
- [PerAda: Parameter-Efficient Federated Learning Personalization with Generalization Guarantees](https://mlsanity.com/paper/2302.06637/) (2023)
- [SAM-Driven Weakly Supervised Nodule Segmentation with Uncertainty-Aware Cross Teaching](https://mlsanity.com/paper/2407.13553/) (2024)

## Built on by (most cited first, 1 of 1)

- [Decouple, Purify and Unite: Semantic-Structural Prototype Learning for Federated Medical Segmentation](https://mlsanity.com/paper/2610.04700/) (2026)

## Abstract (arXiv)

Medical image segmentation is crucial for computer-aided diagnosis, yet privacy constraints hinder data sharing across institutions. Federated learning addresses this limitation, but existing approaches often rely on lightweight architectures that struggle with complex, heterogeneous data. Recently, the Segment Anything Model (SAM) has shown outstanding segmentation capabilities; however, its massive encoder poses significant challenges in federated settings. In this work, we present the first personalized federated SAM framework tailored for heterogeneous data scenarios in medical image segmentation. Our framework integrates two key innovations: (1) a personalized strategy that aggregates only the global parameters to capture cross-client commonalities while retaining the designed L-MoE (Localized Mixture-of-Experts) component to preserve domain-specific features; and (2) a decoupled global-local fine-tuning mechanism that leverages a teacher-student paradigm via knowledge distillation to bridge the gap between the global shared model and the personalized local models, thereby mitigating overgeneralization. Extensive experiments on two public datasets validate that our approach significantly improves segmentation performance, achieves robust cross-domain adaptation, and reduces communication overhead.