# SparseDoctor: Towards Efficient Chat Doctor with Mixture of Experts Enhanced Large Language Models

arXiv: https://arxiv.org/abs/2509.14269 · HTML: https://mlsanity.com/paper/2509.14269/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical and biomedical MoE, one of 12 directions in Mixture-of-experts.
- Builds on 21 of its 40 references that are in the map.
- First posted on arXiv 15 Sep 2025.

## Placed in

- Mixture-of-experts / [Medical and biomedical MoE](https://mlsanity.com/moe/medical-and-biomedical-moe/)

## Builds on (most cited first, 21 of 21)

- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Qwen3 Technical Report](https://mlsanity.com/paper/2505.09388/) (2025)
- [Representation Learning with Contrastive Predictive Coding](https://mlsanity.com/paper/1807.03748/) (2018)
- [ChatGLM: A Family of Large Language Models from GLM-130B to GLM-4 All Tools](https://mlsanity.com/paper/2406.12793/) (2024)
- [Baichuan 2: Open Large-scale Language Models](https://mlsanity.com/paper/2309.10305/) (2023)
- [MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answering](https://mlsanity.com/paper/2203.14371/) (2022)
- [LoraHub: Efficient Cross-Task Generalization via Dynamic LoRA Composition](https://mlsanity.com/paper/2307.13269/) (2023)
- [ChatDoctor: A Medical Chat Model Fine-Tuned on a Large Language Model Meta-AI (LLaMA) Using Medical Domain Knowledge](https://mlsanity.com/paper/2303.14070/) (2023)
- [Gated Attention for Large Language Models: Non-linearity, Sparsity, and Attention-Sink-Free](https://mlsanity.com/paper/2505.06708/) (2025)
- [MixLoRA: Enhancing Large Language Models Fine-Tuning with LoRA-based Mixture of Experts](https://mlsanity.com/paper/2404.15159/) (2024)
- [DoctorGLM: Fine-tuning your Chinese Doctor is not a Herculean Task](https://mlsanity.com/paper/2304.01097/) (2023)
- [CMB: A Comprehensive Medical Benchmark in Chinese](https://mlsanity.com/paper/2308.08833/) (2023)
- [Mixture of Cluster-conditional LoRA Experts for Vision-language Instruction Tuning](https://mlsanity.com/paper/2312.12379/) (2023)
- [Benchmarking Large Language Models on CMExam -- A Comprehensive Chinese Medical Exam Dataset](https://mlsanity.com/paper/2306.03030/) (2023)
- [DISC-MedLLM: Bridging General Large Language Models and Real-World Medical Consultation](https://mlsanity.com/paper/2308.14346/) (2023)
- [LoRAMoE: Alleviate World Knowledge Forgetting in Large Language Models via MoE-Style Plugin](https://mlsanity.com/paper/2312.09979/) (2023)
- [A Survey on Medical Large Language Models: Technology, Application, Trustworthiness, and Future Directions](https://mlsanity.com/paper/2406.03712/) (2024)
- [LLM-MedQA: Enhancing Medical Question Answering through Case Studies in Large Language Models](https://mlsanity.com/paper/2501.05464/) (2024)
- [CMMU: A Benchmark for Chinese Multi-modal Multi-type Question Understanding and Reasoning](https://mlsanity.com/paper/2401.14011/) (2024)
- [Learning an Adaptive Learning Rate Schedule](https://mlsanity.com/paper/1909.09712/) (2019)
- [AcceLLM: Accelerating LLM Inference using Redundancy for Load Balancing and Data Locality](https://mlsanity.com/paper/2411.05555/) (2024)

## Abstract (arXiv)

Large language models (LLMs) have achieved great success in medical question answering and clinical decision-making, promoting the efficiency and popularization of the personalized virtual doctor in society. However, the traditional fine-tuning strategies on LLM require the updates of billions of parameters, substantially increasing the training cost, including the training time and utility cost. To enhance the efficiency and effectiveness of the current medical LLMs and explore the boundary of the representation capability of the LLMs on the medical domain, apart from the traditional fine-tuning strategies from the data perspective (i.e., supervised fine-tuning or reinforcement learning from human feedback), we instead craft a novel sparse medical LLM named SparseDoctor armed with contrastive learning enhanced LoRA-MoE (low rank adaptation-mixture of experts) architecture. To this end, the crafted automatic routing mechanism can scientifically allocate the computational resources among different LoRA experts supervised by the contrastive learning. Additionally, we also introduce a novel expert memory queue mechanism to further boost the efficiency of the overall framework and prevent the memory overflow during training. We conduct comprehensive evaluations on three typical medical benchmarks: CMB, CMExam, and CMMLU-Med. Experimental results demonstrate that the proposed LLM can consistently outperform the strong baselines such as the HuatuoGPT series.