# Double Helix Diffusion for Cross-Domain Anomaly Image Generation

arXiv: https://arxiv.org/abs/2509.12787 · HTML: https://mlsanity.com/paper/2509.12787/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 54 of its 71 references that are in the map.
- First posted on arXiv 16 Sep 2025.

## Builds on (most cited first, 30 of 54)

- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding](https://mlsanity.com/paper/2205.11487/) (2022)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [LAION-5B: An open large-scale dataset for training next generation image-text models](https://mlsanity.com/paper/2210.08402/) (2022)
- [GLIDE: Towards Photorealistic Image Generation and Editing with Text-Guided Diffusion Models](https://mlsanity.com/paper/2112.10741/) (2021)
- [Analyzing and Improving the Image Quality of StyleGAN](https://mlsanity.com/paper/1912.04958/) (2019)
- [Improved Techniques for Training GANs](https://mlsanity.com/paper/1606.03498/) (2016)
- [Describing Textures in the Wild](https://mlsanity.com/paper/1311.3618/) (2013)
- [Null-text Inversion for Editing Real Images using Guided Diffusion Models](https://mlsanity.com/paper/2211.09794/) (2022)
- [GLIGEN: Open-Set Grounded Text-to-Image Generation](https://mlsanity.com/paper/2301.07093/) (2023)
- [Towards Total Recall in Industrial Anomaly Detection](https://mlsanity.com/paper/2106.08265/) (2021)
- [Attend-and-Excite: Attention-Based Semantic Guidance for Text-to-Image Diffusion Models](https://mlsanity.com/paper/2301.13826/) (2023)
- [PaDiM: a Patch Distribution Modeling Framework for Anomaly Detection and Localization](https://mlsanity.com/paper/2011.08785/) (2020)
- [StackGAN: Text to Photo-realistic Image Synthesis with Stacked Generative Adversarial Networks](https://mlsanity.com/paper/1612.03242/) (2016)
- [MultiDiffusion: Fusing Diffusion Paths for Controlled Image Generation](https://mlsanity.com/paper/2302.08113/) (2023)
- [DRAEM -- A discriminatively trained reconstruction embedding for surface anomaly detection](https://mlsanity.com/paper/2108.07610/) (2021)
- [CSI: Novelty Detection via Contrastive Learning on Distributionally Shifted Instances](https://mlsanity.com/paper/2007.08176/) (2020)
- [Anomaly Detection via Reverse Distillation from One-Class Embedding](https://mlsanity.com/paper/2201.10703/) (2022)
- [GANomaly: Semi-Supervised Anomaly Detection via Adversarial Training](https://mlsanity.com/paper/1805.06725/) (2018)
- [Differentiable Augmentation for Data-Efficient GAN Training](https://mlsanity.com/paper/2006.10738/) (2020)
- [CFLOW-AD: Real-Time Unsupervised Anomaly Detection with Localization via Conditional Normalizing Flows](https://mlsanity.com/paper/2107.12571/) (2021)
- [Sub-Image Anomaly Detection with Deep Pyramid Correspondences](https://mlsanity.com/paper/2005.02357/) (2020)
- [Deep Anomaly Detection Using Geometric Transformations](https://mlsanity.com/paper/1805.10917/) (2018)
- [SimpleNet: A Simple Network for Image Anomaly Detection and Localization](https://mlsanity.com/paper/2303.15140/) (2023)
- [SpaText: Spatio-Textual Representation for Controllable Image Generation](https://mlsanity.com/paper/2211.14305/) (2022)
- [Patch SVDD: Patch-level SVDD for Anomaly Detection and Segmentation](https://mlsanity.com/paper/2006.16067/) (2020)
- [Classification-Based Anomaly Detection for General Data](https://mlsanity.com/paper/2005.02359/) (2020)
- [Few-shot Image Generation via Cross-domain Correspondence](https://mlsanity.com/paper/2104.06820/) (2021)
- [Subject-Diffusion:Open Domain Personalized Text-to-Image Generation without Test-time Fine-tuning](https://mlsanity.com/paper/2307.11410/) (2023)

## Abstract (arXiv)

Visual anomaly inspection is critical in manufacturing, yet hampered by the scarcity of real anomaly samples for training robust detectors. Synthetic data generation presents a viable strategy for data augmentation; however, current methods remain constrained by two principal limitations: 1) the generation of anomalies that are structurally inconsistent with the normal background, and 2) the presence of undesirable feature entanglement between synthesized images and their corresponding annotation masks, which undermines the perceptual realism of the output. This paper introduces Double Helix Diffusion (DH-Diff), a novel cross-domain generative framework designed to simultaneously synthesize high-fidelity anomaly images and their pixel-level annotation masks, explicitly addressing these challenges. DH-Diff employs a unique architecture inspired by a double helix, cycling through distinct modules for feature separation, connection, and merging. Specifically, a domain-decoupled attention mechanism mitigates feature entanglement by enhancing image and annotation features independently, and meanwhile a semantic score map alignment module ensures structural authenticity by coherently integrating anomaly foregrounds. DH-Diff offers flexible control via text prompts and optional graphical guidance. Extensive experiments demonstrate that DH-Diff significantly outperforms state-of-the-art methods in diversity and authenticity, leading to significant improvements in downstream anomaly detection performance.